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Der Beitrag von Zytokinen zur Gelenkzerstörung

  • Conference paper
Gelenkzerstörung bei entzündlichen rheumatischen Erkrankungen

Zusammenfassung

Die anatomische Zerstörung der Gelenke bei der chronischen Polyarthritis, die im Zentrum dieses Workshops steht, ist Ausdruck einer Veränderung der synthetischen und degradativen Aktivität von Zellen der artikulären Gewebe. Normalerweise wird die Stabilität der die Zellen umgebenden Matrix durch einen nur geringen Umsatz von Kollagen und Proteoglykanen aufrechterhalten. Die Aktivitäten dieser Zellen werden wohl durch eine Reihe humoraler und anderer Faktoren gesteuert. Bei der Entzündung ist dieses Gleichgewicht gestört. Die Bindegewebszellen machen verschiedene Veränderungen durch: sie bauen Matrix ab, sie können proliferieren und damit zur Bildung von Granulationsgewebe beitragen und sie können sich eventuell an den fibrösen Reparationen nach Beendigung der Entzündung beteiligen.

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Author information

Authors and Affiliations

  1. Strangeways Research Laboratory, Worts’ Cause way, Cambridge, CB1 4RN, England

    Dr. Jeremy Saklatvala

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  1. Dr. Jeremy Saklatvala
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Editor information

Editors and Affiliations

  1. Abteilung Pathologie, Universität Ulm, Oberer Eselsberg, 7900, Ulm/Donau, Germany

    Winfried Mohr

  2. Merckle GmbH, 7900, Ulm/Donau, Germany

    Karl Heinz Emmert

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© 1990 Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt

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Saklatvala, J. (1990). Der Beitrag von Zytokinen zur Gelenkzerstörung. In: Mohr, W., Emmert, K.H. (eds) Gelenkzerstörung bei entzündlichen rheumatischen Erkrankungen. Steinkopff. https://doi.org/10.1007/978-3-642-72450-3_11

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  • DOI: https://doi.org/10.1007/978-3-642-72450-3_11

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-642-72451-0

  • Online ISBN: 978-3-642-72450-3

  • eBook Packages: Springer Book Archive

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