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Pathophysiologie und rationale Pharmakotherapie der Myokardischämie pp 309–328Cite as

Behandlung der Myokardischämie mit Kalziumantagonisten

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Zusammenfassung

Kalzium ist das häufigste Kation im menschlichen Körper. Seine Bewegungen durch die Membran erregbarer Zellen und seine Akkumulation innerhalb der Zelle sind von fundamentaler Bedeutung für die spezifische Aktivität von Geweben. Allgemein ist die Konzentration von Kalzium im Zytosol nur ein geringer Anteil der Kalziumkonzentration im Plasma und weitgehend unabhängig von den normalen Schwankungen im Plasma-Kalzium [12]. Daher liegt eine wesentliche Voraussetzung für die intrazelluläre Kalziumhomöostase in einem sehr präzisen Modulationsmechanismus der Eintritts- und Austrittsrate von Kalzium im Zusammenwirken mit der Funktion des sarkoplasmatischen Retikulums und der Mitochondrien. Eine Steigerung des intrazellulären Kalziums auf abnormal hohe Spiegel kann Zellschäden oder Zelltod verursachen. Zellmembranen weisen eine niedrige Permeabilität für Kalzium auf, das in die Zellen im wesentlichen durch spezifische Kalziumkanäle eintritt.

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  1. Division of Cardiology, Hannover Medical School, Konstanty-Gutschow-Str. 8, 3000, Hannover 61, Germany

    Wolf Rafflenbeul M. D.

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  1. Wolf Rafflenbeul M. D.
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  1. Abteilung für Pathophysiologie, Zentrum für Innere Medizin, Universitätsklinikum Essen, Hufelandstraße 55, D-4300, Essen, Germany

    Gerd Heusch

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© 1990 Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt

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Rafflenbeul, W. (1990). Behandlung der Myokardischämie mit Kalziumantagonisten. In: Heusch, G. (eds) Pathophysiologie und rationale Pharmakotherapie der Myokardischämie. Steinkopff. https://doi.org/10.1007/978-3-642-72437-4_15

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  • DOI: https://doi.org/10.1007/978-3-642-72437-4_15

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-642-72438-1

  • Online ISBN: 978-3-642-72437-4

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