Skip to main content
SpringerLink
Log in
Book cover

Pathophysiologie und rationale Pharmakotherapie der Myokardischämie pp 289–307Cite as

Behandlung der Myokardischämie mit Nitraten

  • Conference paper

Zusammenfassung

Nitrate, die Ester der Salpetersäure mit mehrwertigen Alkoholen, stellen seit über 100 Jahren einen Eckpfeiler der anti-ischämischen Therapie der koronaren Herzerkrankung dar und werden heute nach wie vor in großem Umfang eingesetzt.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Ambrose JA, Winters StL, Stern A, Eng A, Teichholz LE, Goldstein J, Fuster V (1985) Angiographic morphology and the pathogenesis of unstable angina. J Am Coll Cardiol 5: 609–616

    Article  PubMed  CAS  Google Scholar 

  2. von Arnim T, Erath A (1988) Nitrates and calcium antagonists for silent myocardial ischemia. Am J Cardiol 61: 15E - 18E

    Article  Google Scholar 

  3. Bache RJ, Ball RM, Cobb FR, Rembert JC, Greenfield JC Jr (1975) Effects of nitroglycerin on transmural myocardial blood flow in the unanesthetized dog. J Clin Invest 55: 1219–1228

    Article  PubMed  CAS  Google Scholar 

  4. Balard JM (1844) Premier memoire sur 1 alcool amylique. Ann Chim Phys 12: 294–330

    Google Scholar 

  5. Bernstein L, Friesinger GC, Lichtlen PR, Ross RS (1966) The effect of nitroglycerin on the systemic and coronary circulation in man and dogs. Circulation 33: 107–116

    PubMed  CAS  Google Scholar 

  6. Blasini R, Froer KL, Blümel G, Rudolph W (1982) Wirkungsverlust von Isosorbiddinitrat bei Langzeitbehandlung der chronischen Herzinsuffizienz. Herz 7: 250–258

    PubMed  CAS  Google Scholar 

  7. Blasini R, Reiniger G, Brügmann U, Rudolph W (1984) Vermeidung einer Toleranzentwicklung unter Isosorbiddinitrat durch Intervalltherapie. Herz 9: 166–170

    PubMed  CAS  Google Scholar 

  8. Blasini R, Brügmann U, Reiniger G, Rudolph W (1985) Langzeittherapie der Belastungs Angina-pectoris durch einmal tägliche Verabreichung von 120 mg Isosorbiddinitrat in retardierter Form. Vergleich von Monotherapie und Kombinationstherapie mit Atenolol und Nifedipin. Herz 10: 163–171

    CAS  Google Scholar 

  9. Bjerlöv H (1943) A new drug against angina pectoris. Svenska Läk-Tidn 40: 449

    Google Scholar 

  10. Borer JS, Redwood DR, Levitt B, Cagin N, Bianchi C, Vallin H, Epstein St (1975) Reduction in myocardial ischemia with nitroglycerin or nitroglycerin plus phenylephrine administered during acute myocardial infarction. N Engl J Med 293: 1008–1012

    Article  PubMed  CAS  Google Scholar 

  11. Brown BG, Bolson E, Petersen RB, Pierce CD, Dodge HT (1981) The mechanisms of nitroglycerin action: stenosis vasodilatation as a major component of the drug response. Circulation 64: 1089–1097

    Article  PubMed  CAS  Google Scholar 

  12. Brunton TL (1867) Use of nitrite of amyl in angina pectoris. Lancet II: 97–98

    Article  Google Scholar 

  13. Busse R, Bassenge E (1982) Einfluß von Nitraten, nitratähnlichen Substanzen, Calcium-Antagonisten and ß-Rezeptorenblockern auf den peripheren Kreislauf. Herz 7: 388–405

    PubMed  CAS  Google Scholar 

  14. Bussmann W-D, Passek D, Seidel W, Kaltenbach M (1981) Reduction of CK and CK-MB indexes of infarct size by intravenous nitroglycerin. Circulation 63: 615–622

    Article  PubMed  CAS  Google Scholar 

  15. DeCaterina R, Giannessi D, Crea F, Chierchia S, Bernini W, Gazzetti P, L’Abbate A (1984) Inhibition of platelet function by injectable isosorbide dinitrate. Am J Cardiol 53: 1683–1687

    Article  CAS  Google Scholar 

  16. Cowan JC, Bourke JP, Reid DS, Julian DG (1987) Prevention of tolerance to nitroglycerin patches by overnight removal. Am J Cardiol 60: 271–275

    Article  PubMed  CAS  Google Scholar 

  17. Danahy DT, Burwell DT, Aronow WS, Prakash R (1977) Sustained hemodynamic and anti-anginal effect of high dose oral isosorbide dinitrate. Circulation 55: 381–387

    PubMed  CAS  Google Scholar 

  18. Davies MJ, Thomas AC, Knapman PA, Hangartner JR (1986) Intramyocardial platelet aggregation in patients with unstable angina suffering sudden ischemic cardiac death. Circulation 73: 418–427

    Article  PubMed  CAS  Google Scholar 

  19. Dirschinger J, Fleck E, Redl A, Brandt R, Späth M, Mannes YG, Recke S, Hall D, Rudolph W (1977) Effects of sodium nitroprusside and isosorbide dinitrate on regional myocardial blood flow in patients with coronary artery disease and left ventricular asynergy. Herz 2: 71–74

    Google Scholar 

  20. Distante A, Maseri A, Severi S, Biagini A, Chierchia S (1979) Management of vasospastic angina at rest with continuous infusion of isosorbide dinitrate. Am J Cardiol 44: 533–539

    Article  PubMed  CAS  Google Scholar 

  21. Evans W, Hoyle C (1933) The comparative value of drugs used in the continuous treatment of angina pectoris. Quart J Med 2: 311–338

    Google Scholar 

  22. Falk E (1985) Unstable angina with fatal outcome: Dynamic coronary thrombosis leading to infarction and/or sudden death. Autopsy evidence of current mural thrombosis with peripheral embolization culminating in total vascular occlusion. Circulation 71: 699–708

    Article  PubMed  CAS  Google Scholar 

  23. Feelisch M, Noack E, Schröder H (1988) Explanation of the discrepancy between the degree of organic nitrate decomposition, nitrite formation and guanylate cyclase stimulation. Europ Heart J 9 (Suppl A): 57–62

    CAS  Google Scholar 

  24. Fitzgerald DJ, Roy L, Catella F, Fitzgerald GA (1986) Platelet activation in unstable coronary disease. N Engl J Med 315: 983–989

    Article  PubMed  CAS  Google Scholar 

  25. Flaherty JT, Come PC, Baird MG, Rouleau J, Taylor DR, Weisfeldt ML, Greene HL, Becker LC, Pitt B (1976) Effects of intravenous nitroglycerin on left ventricular function and ST segment changes in acute myocardial infarction. Br Heart J 38: 612–621

    Article  PubMed  CAS  Google Scholar 

  26. Flaherty JT, Becker LC, Bulkley BH, Weiss JL, Gerstenblith G, Kaltman CH, Silverman KJ, Wei JY, Pitt B, Weisfeldt ML (1983) A randomized prospective trial of intravenous nitroglycerin in patients with acute myocardial infarction. Circulation 68: 576–588

    Article  PubMed  CAS  Google Scholar 

  27. Flaherty JT (1987) Role of nitrates in acute myocardial infarction. Am J Cardiol 60: 35–38

    Article  Google Scholar 

  28. Guist van WH, deGraeff PA, Scholtens E, deLangen CDJ, Wesseling H (1987) Potentiation of isosorbide dinitrate-induced coronary dilatation by captopril. J Cardiovasc Pharmacol 9: 254–255

    Article  Google Scholar 

  29. Goldberg L (1948) Pharmacological properties of sorbide dinitrate. Acta Physiol Scand 15: 173–187

    Article  PubMed  CAS  Google Scholar 

  30. Gold HK, Leinbach RC, Sanders CA (1972) Use of sublingual nitroglycerin in congestive failure following acute myocardial infarction. Circulation 46: 839–845

    PubMed  CAS  Google Scholar 

  31. Goldstein RE, Rosing DR, Redwood DR, Beiser GD, Epstein SE (1971) Clinical and circulatory effects of isosorbide dinitrate. Comparison with nitroglycerin. Circulation 43: 629–640

    CAS  Google Scholar 

  32. Goldstein RE (1982) Coronary vascular responses to vasodilator drugs. Progr Cardiovasc Dis 24: 419–436

    Article  CAS  Google Scholar 

  33. Gottlieb SO, Weisfeldt ML, Ouyang P, Mellits ED, Gerstenblith G (1987) Silent ischemia predicts infarction and death during 2 year follow-up of unstable angina. J Am Coll Cardiol 10: 756–760

    Article  PubMed  CAS  Google Scholar 

  34. Guthrie F (1859) Nitrite of amyl and its derivates. Chem Soc 11: 245–252

    Google Scholar 

  35. Hausmann D, Nikutta P, Daniel WG, Lichtlen PR (1988) Therapie der stummen Myokardischämie: Wirkung von 1 x 120 mg retardiertem Isosorbiddinitrat bei stabiler Angina pectoris. Z Kardiol 77 (Suppl 1 ): 83 (abstr.)

    Google Scholar 

  36. Hering C (1849) Glonoin. Kirby. N Am J Homeopathy May

    Google Scholar 

  37. Hess OM, Schneider J, Nonogi H, Carroll JD, Schneider K, Turina M, Krayenbuehl HP (1988) Myocardial structure in patients with exercise-induced ischemia. Circulation 77: 967–977

    Article  PubMed  CAS  Google Scholar 

  38. Horowitz JD, Henry CA, Syrjanen ML, Louis WJ, Fish RD, Smith TW, Antman EM (1988) Comined use of nitroglycerin and N-acetylcysteine in the management of unstable angina pectoris. Circulation 77: 787–794

    Article  PubMed  CAS  Google Scholar 

  39. Horwitz LD, Herman MV, Gorlin R (1972) Clinical response to nitroglycerin as a diagnostic test for coronary artery disease. Am J Cardiol 29: 149–153

    Article  PubMed  CAS  Google Scholar 

  40. Ignarro LJ, Lippton H, Edwards JC, Baricous WH, Hyman AL, Kadowitz PJ, Gruetter CA (1981) Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: Evidence for the involvement of S-nitrosothiols as active intermediates. J Pharmacol Exp Ther 218: 739–749

    PubMed  CAS  Google Scholar 

  41. Jaffe AS, Geltman EM, Tiefenbrunn AJ, Ambos HD, Strauss HD, Sobel BE, Roberts R (1983) Reduction of infarct size in patients with inferior infarction with intravenous glyceryl trinitrate. A randomized study. Br Heart J 49: 452–460

    Article  CAS  Google Scholar 

  42. Jugdutt BI, Warnica JW (1988) Intravenous nitroglycerin therapy to limit myocardial infarct size, expansion, and complications. Effect of timing, dosage, and infarct location. Circulation 78: 906–919

    Article  PubMed  CAS  Google Scholar 

  43. Kaplan K, Davison R, Parker M, Przybylek J, Teagarden JR, Lesch M (1983) Intravenous nitroglycerin for the treatment of angina at rest unresponsive to standard nitrate therapy. Am J Cardiol 51: 694–698

    Article  PubMed  CAS  Google Scholar 

  44. Kattus AA, Alvaro AB, Zohmann LR, Coulson AH (1979) Comparison of placebo, nitroglycerin and isosorbide dinitrate for effectiveness of relief of angina and duration of action. Chest 75: 17–23

    Article  PubMed  CAS  Google Scholar 

  45. Krantz JC Jr, Carr CJ, Forman SE, Cone N (1940) A contribution to the mechanism of the action of organic nitrates. J Pharmacol Exp Ther 70: 323–327

    CAS  Google Scholar 

  46. Kukovetz WR, Holzmann S (1983) Mechanism of nitrate-induced vasodilatation and tolerance. Z Kardiol 72 (Suppl 3): 14–19

    PubMed  CAS  Google Scholar 

  47. Lehmann G, Reiniger G, Rudolph W (1988) Wie effektiv ist eine Kombination eines Nitrates und eines Calciumantagonisten bei Patienten mit stabiler Angina pectoris. Z Kardiol 77 (Suppl 1 ): 119 (abstr.)

    Google Scholar 

  48. Levy WS, Katz RJ, Wassermann AG (1989) Methionine reverses tolerance to transdermal nitroglycerin. J Am Coll Cardiol 13: 230A (abstr.)

    Google Scholar 

  49. Macho P, Vatner SF (1981) Effects of nitroglycerin and nitroprusside on large and small coronary vessels in conscious dogs. Circulation 64: 1101–1107

    Article  PubMed  CAS  Google Scholar 

  50. McGregor M (1982) The nitrates and myocardial ischemia. Circulation 66: 689–692

    Article  PubMed  CAS  Google Scholar 

  51. Moise A, Théroux P, Taeymans Y, Descoings B, Lespérance J, Waters DD, Pelletier GB, Bourassa MG (1983) Unstable angina and progression of coronary atherosclerosis. N Engl J Med 309: 685–689

    Article  PubMed  CAS  Google Scholar 

  52. Murrell W (1879) Nitroglycerin as a remedy for angina pectoris. Lancet I:80,113,225,642 —646

    Google Scholar 

  53. Nabel EG, Barry J, Rocco MB, Campbell St, Mead K, Fenton T, Orav EJ, Selwyn AP (1988) Variability of transient myocardial ischemia in ambulatory patients with coronary artery disease. Circulation 78: 60–67

    Article  PubMed  CAS  Google Scholar 

  54. Nademanee K, Intacharot V, Josephson MA, Rieders D, Mody FV, Singh BN (1987) Prognostic significance of silent myocardial ischemia in patients with unstable angina. J Am Coll Cardiol 10: 1–9

    Article  PubMed  CAS  Google Scholar 

  55. Noack E (1982) Therapie der Angina pectoris. Pharmakologische Basis für die Therapie mit organischen Nitraten. Herz 7: 275–285

    PubMed  CAS  Google Scholar 

  56. Page A, Gateau P, Ohayon J, Couppillaud J, LeMinh D, Besse P (1981) Intravenous nitroglycerin in unstable angina. In: Lichtlen PR, Engel HJ, Schrey A, Swan HJC (eds) Nitrates III. Cardiovascular effects. Springer, Berlin Heidelberg New York, p 371–376

    Chapter  Google Scholar 

  57. Parker JO, van Koughnett KA, Farrell B (1985) Comparison of buccal nitroglycerin and oral isosorbide dinitrate for nitrate tolerance in stable angina pectoris. Am J Cardiol 56: 724–728

    Article  PubMed  CAS  Google Scholar 

  58. Parker JO, van Koughnett KA, Fung HL (1984) Transdermal isosorbide dinitrate in angina pectoris: effect of acute and sustained therapy. Am J Cardiol 54: 8–13

    Article  PubMed  CAS  Google Scholar 

  59. Reiniger G, Kraus F, Dirschinger J, Blasini R, Rudolph W (1985) Hochdosierte transdermale Nitroglycerintherapie: Wirkungsverlust innerhalb von 24 Stunden? Herz 10: 157–162

    PubMed  CAS  Google Scholar 

  60. Reiniger G, Menke G, Boertz A, Kraus F, Rudolph W (1987) Intervalltherapie zur effektiven Behandlung der Angina pectoris mit Nitroglycerin-Pflaster-Systemen. Kontrollierte Studie mit Bestimmung der Nitroglycerin-Plasmaspiegel. Herz 12: 68–73

    CAS  Google Scholar 

  61. Reiniger G, Rudolph W (1987) Diskontinuierliche Wirkstoffreisetzung als Alternative zur Intervalltherapie bei der Behandlung der koronaren Herzerkrankung mit Nitroglycerinpflastern. Herz 12: 348–353

    PubMed  CAS  Google Scholar 

  62. Rocco MB, Nabel EG, Campbell St, Goldman L, Barry J, Mead K, Selwyn AP (1988) Prognostic importance of myocardial ischemia detected by ambulatory monitoring in patients with stable coronary artery disease. Circulation 78: 877–884

    Article  PubMed  CAS  Google Scholar 

  63. Rudolph W, Blasini R, Froer KL, Brügmann U, Mannes A, Hall D (1981) Effects of acute and chronic administration of isosorbide dinitrate, sustained-release form, in patients with angina pectoris. In: Lichtlen PR, Engel HJ, Schrey A, Swan HJC (eds) Nitrates III. Cardiovascular effects. Springer, Berlin Heidelberg New York, p 75–81

    Chapter  Google Scholar 

  64. Rudolph W, Blasini R, Kraus F (1982) Klinische Wirksamkeit der Nitrate bei Belastungs Angina-pectoris. Herz 7: 287–295

    PubMed  CAS  Google Scholar 

  65. Rudolph W, Blasini R, Reiniger G, Brügmann U (1983) Tolerance development during isosorbide dinitrate treatment: can it be circumvented? Z Kardiol 72 (Suppl 3): 195–198

    PubMed  Google Scholar 

  66. Rudolph W, Blasini R (1984) Nitrate tolerance: A relevant clinical problem? Herz 9: 115–122

    PubMed  CAS  Google Scholar 

  67. Rudolph W, Dirschinger J, Reiniger G, Beyerle A, Hall D (1988) When does nitrate tolerance develop? What dosages and which intervals are necessary to ensure maintained effectiveness? Eur Heart J 9 (Suppl A): 63–72

    PubMed  Google Scholar 

  68. Rudolph W, Dirschinger J, Hall D, Reiniger G, Beyerle A (1989) Effectiveness of interval therapy in angina pectoris. Eur Heart J 10 (Suppl A): 50–55

    PubMed  Google Scholar 

  69. Schirnick C, Reifart N (1988) Akute and subchronische Wirkung eines Pflasters mit diskontinuierlicher Nitroglycerinfreisetzung. Z Kardiol 77 (Suppl 1 ): 82 (abstr.)

    Google Scholar 

  70. Sherman CT, Litvack F, Grundfest W, Lee M, Hickey A, Chaux A, Kass R, Blanche C, Matloff J, Morgenstern L, Ganz W (1986) Coronary angioscopy in patients with unstable angina pectoris. N Engl J Med 315: 913–919

    Article  PubMed  CAS  Google Scholar 

  71. Sobrero A (1847) Sur pluriers composes detonants produc avec 1 acide nitrique et le sucre, la lactine, la mannite et la glycerine. R Acad Sci (Paris) 24: 247–248

    Google Scholar 

  72. Stewart DD (1888) Remarkable tolerance to nitroglycerin. Philadelphia Policlinic 172

    Google Scholar 

  73. Thadani U, Manyari D, Parker JO, Fung HL (1980) Tolerance to the circulatory effects of oral isosorbide dinitrate. Rate of development and cross-tolerance to glyceryl trinitrate. Circulation 61: 526–535

    PubMed  CAS  Google Scholar 

  74. Tzivoni D, Weisz G, Gavish A, Zin D, Keren A, Stern S (1989) Comparison of mortality and myocardial infarction rates in stable angina pectoris with and without ischemic episodes during daily activities. Am J Cardiol 63: 273–276

    Article  PubMed  CAS  Google Scholar 

  75. Weiner DA, Ryan TJ, McCabe CH, Luk S, Chaitman BR, Sheffield LT, Tristani F, Fisher LD (1987) Significance of silent myocardial ischemia during exercise testing in patients with coronary artery disease. Am J Cardiol 59: 725–729

    Article  PubMed  CAS  Google Scholar 

  76. Weiner DA, Ryan TJ, McCabe CH, Ng G, Chaitman BR, Sheffield LT, Tristani FE, Fisher LD (1988) Risk of developing an acute myocardial infarction or sudden coronary death in patients with exercise-induced silent myocardial ischemia. A report from the coronary artery surgery study ( CASS) registry. Am J Cardiol 62: 1155–1158

    Article  PubMed  CAS  Google Scholar 

  77. Vatner SF, Heyndrickx GR (1975) Mechanism of action of nitroglycerin: Coronary, cardiac, and systemic effects. In: Needleman P (ed) Organic Nitrates. Springer, Berlin Heidelberg New York, p 131–161

    Google Scholar 

  78. Yusuf S, Collins R, MacMahon St, Peto R (1988) Effect of intravenous nitrates on mortality in acute myocardial infarction: An overview of the randomized trials. Lancet I: 1088–1092

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik für Herz- und Kreislauferkrankungen, Deutsches Herzzentrum München, Lothstraße 11, 8000, München 2, Deutschland

    Prof. Dr. Werner Rudolph, Günter Reiniger, Josef Dirschinger & Felicitas Kraus

Authors
  1. Prof. Dr. Werner Rudolph
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Günter Reiniger
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Josef Dirschinger
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Felicitas Kraus
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Abteilung für Pathophysiologie, Zentrum für Innere Medizin, Universitätsklinikum Essen, Hufelandstraße 55, D-4300, Essen, Germany

    Gerd Heusch

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt

About this paper

Cite this paper

Rudolph, W., Reiniger, G., Dirschinger, J., Kraus, F. (1990). Behandlung der Myokardischämie mit Nitraten. In: Heusch, G. (eds) Pathophysiologie und rationale Pharmakotherapie der Myokardischämie. Steinkopff. https://doi.org/10.1007/978-3-642-72437-4_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-72437-4_14

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-642-72438-1

  • Online ISBN: 978-3-642-72437-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation