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Dual distribution of cardiac hormones (CDD/ANP) in the heart and brain of vertebrates

  • M. Reinecke
  • D. Betzler
  • H. Segner
  • W. G. Forssmann

Abstract

About four years ago, several research groups independently isolated and characterized cardiac hormones from the atrial appendages of some mammalian species. As a consequence of the different isolation procedures and the accompaning bioassays (diuresis-natriuresis, vasodilation) used, a variety of cardiac hormone candidates were presented under different names (3,7,20). However, mainly based on cDNA studies (13,17,18,28) it recently became evident that the different peptides are members of the same family and are derived from a preprohormone, which is cleaved resulting in a peptide of 126 amino acids, i.e., gamma-ANP (15) or cardiodilatin- (CDD-) 126 (8,9). This prohormone contains in its C-terminal portion the final circulating form consisting of 28 amino acids, i.e. alpha-ANP (14) which is identical to CDD-28 (99–126) (7).

Keywords

Atrial Natriuretic Peptide Atrial Appendage Atrial Natriuretic Factor Specific Granule Vertebrate Classis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Dr. Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt 1989

Authors and Affiliations

  • M. Reinecke
    • 1
  • D. Betzler
    • 1
  • H. Segner
    • 1
  • W. G. Forssmann
    • 1
  1. 1.Department of Anatomy and Cell BiologyUniversity of HeidelbergHeidelbergGermany

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