Receptor binding of cardiac hormones to dog kidney with congestive heart failure
During chronic and acute cardiac failure, plasma levels of cardiodilatin/atrial natriuretic peptide (CDD/ANP) are elevated, depending on the severity of the disease. Compared to normal subjects, however, CDD/ANP infusion in high doses in patients with chronic heart failure showed no significantly increased urine or sodium excretion rates (1,6). It was reported that in platelets from patients with congestive heart failure, binding sites for CDD/ANP are lower than in controls (9). Down-regulation of CDD/ANP receptors in cultured vascular smooth muscle cells during incubation with ANP has been reported (3), and Takayanagi and collaborators (11) observed that the number of ANP receptors was reduced in aortic smooth muscle of spontaneous hypertensive rats during hypertension. The loss of the biological activity of CDD/ANP with respect to diuresis during congestive heart failure may be due to a receptor down-regulation in the kidney. Therefore, we investigated binding of CDD/ANP in an animal model of congestive heart failure.
KeywordsCongestive Heart Failure Atrial Natriuretic Peptide Atrial Natriuretic Factor Tyrode Solution Human Atrial Natriuretic Peptide
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