Receptor binding of cardiac hormones to dog kidney with congestive heart failure

  • M. Gagelmann
  • K. Forssmann
  • A. Whalley
  • G. A. J. Riegger
  • W. G. Forssmann
Conference paper


During chronic and acute cardiac failure, plasma levels of cardiodilatin/atrial natriuretic peptide (CDD/ANP) are elevated, depending on the severity of the disease. Compared to normal subjects, however, CDD/ANP infusion in high doses in patients with chronic heart failure showed no significantly increased urine or sodium excretion rates (1,6). It was reported that in platelets from patients with congestive heart failure, binding sites for CDD/ANP are lower than in controls (9). Down-regulation of CDD/ANP receptors in cultured vascular smooth muscle cells during incubation with ANP has been reported (3), and Takayanagi and collaborators (11) observed that the number of ANP receptors was reduced in aortic smooth muscle of spontaneous hypertensive rats during hypertension. The loss of the biological activity of CDD/ANP with respect to diuresis during congestive heart failure may be due to a receptor down-regulation in the kidney. Therefore, we investigated binding of CDD/ANP in an animal model of congestive heart failure.


Congestive Heart Failure Atrial Natriuretic Peptide Atrial Natriuretic Factor Tyrode Solution Human Atrial Natriuretic Peptide 
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  1. 1.
    Crozier, I.G., Nicholls, M.G., Ikram, H., Espiner, E.A., Cornez, H.J., Warner, N.J. (1986) Hemodynamic effects of atrial peptide infusion in heart failure. Lancet 2: 1242PubMedCrossRefGoogle Scholar
  2. 2.
    Forssmann, W.G., Pickel, V., Reinecke, M., Hock, D., Metz, J. (1981) Immunohistochemistry and immunocytochemistry of nervous tissue. In: Heym, C., Forssmann, W.G. (eds) Techniques in neuro anatomical research. Springer, Berlin Heidelberg New York, p 171Google Scholar
  3. 3.
    Hirata, Y., Tomita, M., Takada, S., Yoshimi, H. (1985) Vascular receptor binding activities and cyclic GMP responses by synthetic human and rat atrial natriuretic peptides (ANP) and receptor down-regulation by ANP. Biochem Biophys Res Commun 128: 538PubMedCrossRefGoogle Scholar
  4. 4.
    Ishikawa, Y., Umemura, S., Yasuda, G., Uchino, K., Shindou, T., Minamizawa, K., Toya, Y., Kaneko, Y. (1987) Identification of an atrial natriuretic peptide specific receptor in human kidney. Biochem Biophys Res Commun 147: 135PubMedCrossRefGoogle Scholar
  5. 5.
    Napier, M.A., Vandlen, R.L., Albers-Schöberg, G., Nutt, R.F., Brady, S., Lyle, T., Winquist, R., Faison, E.P., Heinel, L.A., Blaine, E.H. (1984) Specific membrane receptors for atrial natriuretic factor in renal and vascular tissues. Proc Natl Acad Sci USA 81: 5946PubMedCrossRefGoogle Scholar
  6. 6.
    Riegger, A.J. G., Kromer, E.P., Kochsiek, K. (1986) Human atrial natriuretic peptide: plasma levels, hemodynamic, hormonal and renal effects in patients with severe congestive heart failure. J Cardiovasc Pharmacol 8: 1107PubMedCrossRefGoogle Scholar
  7. 7.
    Riegger, A.J.G., Eisner, D., Muders, F., Pascher, E., Kromer, E.P. (1988) Endocrine heart in experimental cardiomyopathy. In: Functional morphology of the endocrine heart, pp 153–159. Forssmann, W.G., Schnermann, D.D., Alt, J. (eds) Steinkopff Verlag DarmstadtGoogle Scholar
  8. 8.
    Scarborough, R.M., Schenk, D.B., McEnroe, G.A., Arfsten, A., Kang, L.-L., Schwartz, K., Lewicki, J.A. (1986) Truncated atrial natriuretic peptide analogs. J Biol Chem 261: 12960PubMedGoogle Scholar
  9. 9.
    Schiffrin, E.L. (1986) Down-regulation of binding sites for atrial natriuretic peptide in platelets of patients with congestive heart failure. Circulation 74 (suppl II): II-463 (abstract)Google Scholar
  10. 10.
    Takayanagi, R., Imada, T., Grammer, R.T., Misono, K.S., Naruse, M., Inagami, T. (1986) Atrial natriuretic factor in spontaneously hypertensive rats: concentration changes with the progression of hypertension and elevated formation of cyclic GMP. J Hypertension 4: S303Google Scholar
  11. 11.
    Takayanagi, R., Snajdar, R.M., Imada, T., Tamura, M., Pandey, K.N., Misono, K.S., Inagami, T. (1987) Purification and characterization of two types of atrial natriuretic factor receptors from bovine adrenal cortex: guanylate cyclase-linked and cyclase-free receptors. Biochem Biophys Res Commun 144: 244PubMedCrossRefGoogle Scholar

Copyright information

© Dr. Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt 1989

Authors and Affiliations

  • M. Gagelmann
    • 1
  • K. Forssmann
    • 1
  • A. Whalley
    • 1
  • G. A. J. Riegger
    • 2
  • W. G. Forssmann
    • 1
  1. 1.Department of Anatomy and Cell BiologyUniversity of HeidelbergGermany
  2. 2.Medical University ClinikWürzburgGermany

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