Atrial natriuretic peptide in term newborn infants

  • A. Timnik
  • J. Weil
  • M. Brügmann
  • T. Strom
  • M. Haufe
  • J. M. Heim
  • R. Gerzer
Conference paper

Summary

The aim of this study was to measure plasma and urinary levels of atrial natriuretic peptide (ANP) and cyclic guanosine 3′5′ monophosphate (cGMP) in term newborn infants (n=25) aged one to six days.

Plasma ANP and cGMP levels were significantly higher in umbilical venous blood and in peripheral venous blood of infants aged two to four days than in older control infants aged 30 days to 12 months (n=24, p<0.01). There was a linear correlation between the two parameters (r=0.71, p<0.001).

Furthermore, in contrast to ANP, a linear correlation was found between plasma and urinary cGMP levels (r=0.69, p<0.02). Therefore, urinary cGMP — but not ANP -excretion seems to reflect plasma cGMP concentrations to a certain extent. Additionally, an age dependence of urinary cGMP excretion was found that showed significantly higher values in infants aged one to three days than in infants aged four to six days (p<0.01). There was no influence of elevated ANP or cGMP levels on urinary sodium excretion or urine volume.

Keywords

Angiotensin Renin Aldosterone Vasopressin Monophosphate 

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References

  1. 1.
    Gerzer, R., Weil, J., Strom, T., Müller, T. (1986) Mechanisms of action of actrial natriuretic factor: clinical consequences. Klin Wochenschr 64 (suppl VI): 21–26PubMedGoogle Scholar
  2. 2.
    Gerzer, R., Heim, J.M., Schütte, B., Weil, J. (1987) Cellular mechanism of action of actial natriuretic factor Klin Wochenschr 65 (suppl VIII): 109–114PubMedGoogle Scholar
  3. 3.
    Heim, J.M., Gottmann, K., Weil, J., Haufe, M.C., Gerzer, R. (1987) Is cyclic GMP a useful marker for ANF action? Z Kardiol (in press)Google Scholar
  4. 4.
    Lang, R.E., Thölken, H., Ganten, D., Luft, F.C., Ruskoaho, H., Unger, T. (1985) Atrial natriuretic factor — a circulating hormone stimulated by volume loading. Nature 314: 264–266PubMedCrossRefGoogle Scholar
  5. 5.
    Leake, R.D., Weitzman, R.E. (1980) The fetal-maternal neurohypophysiological system. In: Tulchinsky, D., Ryan, K.J. (eds) Maternal-fetal Endocrinology, 1st edn WB Sanders, Philadelphia, pp 233–241Google Scholar
  6. 6.
    Strom, T., Weil, J., Bidlingmaier, F. (1987) Platelet receptors for atrial natriuretic peptide in man. Life Sci 40: 769–773PubMedCrossRefGoogle Scholar
  7. 7.
    Strom, T., Weil, J., Timnik, A., Knorr, D., Bidlingmaier, F. (1987, Abstract) Binding sites for atrial natriuretic peptide (ANP) on platelets in patients with high plasma ANP levels. Pediatr Res (in press)Google Scholar
  8. 8.
    Tulassay, T., Rascher, W., Seyberth, H.J., Lang, R.E., Toth, M., Sulyok, E. (1986) Role of atrial natriuretic peptide in sodium homeostasis in premature infants. J Pediatr 109: 1023–1027PubMedCrossRefGoogle Scholar
  9. 9.
    Weil, J., Lang, R.E., Suttmann, H., Rampf, U., Bidlingmaier, F., Gerzer, R. (1985) Concomittant increase of plasma atrial natriuretic peptide and cyclic GMP during volume loading. Klin Wochenschr 63: 1265–1268PubMedCrossRefGoogle Scholar
  10. 10.
    Weil, J., Bidlingmaier, F., Döhlemann, C., Kuhnle, U., Strom, T., Lang, R.E. (1986) Comparison of plasma atrial natriuretic peptide levels in healthy children from birth to adolescence and in children with cardiac diseases. Pediatr Res 20: 1328–1331PubMedCrossRefGoogle Scholar
  11. 11.
    Weil, J., Gerzer, R., Strom, T., Lang, R.E., Döhlemann, C., Knorr, D., Bidlingmaier, F. (1987) Increased plasma cyclic guanosine monophosphate concentrations in children with high levels of circulating atrial natriuretic peptide Pediatrics 80: 545–548PubMedGoogle Scholar
  12. 12.
    Yamaji, T., Hirai, N., Ishibashi, M., Takaku, F., Yanaihara, T., Nakayama, T. (1986) Atrial natriuretic peptide in umbilical cord blood: evidence for circulating hormone in human foetus. J Clin Endocrinol Metab 63: 1414–1417PubMedCrossRefGoogle Scholar

Copyright information

© Dr. Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt 1989

Authors and Affiliations

  • A. Timnik
    • 1
  • J. Weil
    • 1
  • M. Brügmann
    • 1
  • T. Strom
    • 1
  • M. Haufe
    • 2
  • J. M. Heim
    • 2
  • R. Gerzer
    • 2
  1. 1.Department of PediatricsUniversity of MunichGermany
  2. 2.Department of MedicineUniversity of MunichGermany

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