Atrial natriuretic peptide in term newborn infants
The aim of this study was to measure plasma and urinary levels of atrial natriuretic peptide (ANP) and cyclic guanosine 3′5′ monophosphate (cGMP) in term newborn infants (n=25) aged one to six days.
Plasma ANP and cGMP levels were significantly higher in umbilical venous blood and in peripheral venous blood of infants aged two to four days than in older control infants aged 30 days to 12 months (n=24, p<0.01). There was a linear correlation between the two parameters (r=0.71, p<0.001).
Furthermore, in contrast to ANP, a linear correlation was found between plasma and urinary cGMP levels (r=0.69, p<0.02). Therefore, urinary cGMP — but not ANP -excretion seems to reflect plasma cGMP concentrations to a certain extent. Additionally, an age dependence of urinary cGMP excretion was found that showed significantly higher values in infants aged one to three days than in infants aged four to six days (p<0.01). There was no influence of elevated ANP or cGMP levels on urinary sodium excretion or urine volume.
KeywordsAtrial Natriuretic Peptide Newborn Infant cGMP Level Peripheral Venous Blood Urinary Sodium Excretion
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