Renin, sodium and hypertension

  • G. Macdonald

Abstract

Although the secretion of renin has been shown to be influenced at different levels by many mechanisms — beta adrenergic activity, intracellular calcium concentration, plasma angiotensin II concentration, atrial natriuretic factor, afferent arteriolar distension — regulation of the renin-angiotensin system remains closely linked to sodium metabolism. Its functional activity throughout the body increases in states of sodium depletion and decreases during high dietary sodium intake, administration of mineralocorticoids or other manoeuvres which expand extracellular space.

Keywords

Angiotensin Posit Renin Aldosterone Phenylephrine 

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  24. Author’s address: Graham Macdonald University of New South Wales School of Medicine The Prince Henry Hospital Little Bay, NSW AustraliaGoogle Scholar

Copyright information

© Dr. Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt 1989

Authors and Affiliations

  • G. Macdonald
    • 1
  1. 1.School of Medicine, The Prince Henry HospitalUniversity of New South WalesLittle BayAustralia

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