Renin, sodium and hypertension

  • G. Macdonald


Although the secretion of renin has been shown to be influenced at different levels by many mechanisms — beta adrenergic activity, intracellular calcium concentration, plasma angiotensin II concentration, atrial natriuretic factor, afferent arteriolar distension — regulation of the renin-angiotensin system remains closely linked to sodium metabolism. Its functional activity throughout the body increases in states of sodium depletion and decreases during high dietary sodium intake, administration of mineralocorticoids or other manoeuvres which expand extracellular space.


Atrial Natriuretic Peptide Vasoactive Intestinal Peptide Atrial Natriuretic Factor Renin Secretion Sodium Depletion 
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© Dr. Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt 1989

Authors and Affiliations

  • G. Macdonald
    • 1
  1. 1.School of Medicine, The Prince Henry HospitalUniversity of New South WalesLittle BayAustralia

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