Epithelial adhesion of urease-induced crystals in the urinary tract
The primary prerequisite for the formation of infection stones, composed of struvite and calcium phosphate, is supersaturation of the stone-forming minerals in urine, due to the action of urease-producing micro-organisms (4). However, it is a common experience that not all patients infected with urea-splitting micro-organisms develop urinary tract stones. This may partly be explained by crystallization inhibitors in urine, active against urease-induced crystallization. Such activity has recently been detected in human urine (3).
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