Epithelial adhesion of urease-induced crystals in the urinary tract

  • Lars Grenabo
  • H. Hedelin
  • J. Hugosson
  • S. Pettersson
Conference paper
Part of the Fortschritte der Urologie und Nephrologie book series (2824, volume 26)


The primary prerequisite for the formation of infection stones, composed of struvite and calcium phosphate, is supersaturation of the stone-forming minerals in urine, due to the action of urease-producing micro-organisms (4). However, it is a common experience that not all patients infected with urea-splitting micro-organisms develop urinary tract stones. This may partly be explained by crystallization inhibitors in urine, active against urease-induced crystallization. Such activity has recently been detected in human urine (3).


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Copyright information

© Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt 1988

Authors and Affiliations

  • Lars Grenabo
    • 1
  • H. Hedelin
    • 1
  • J. Hugosson
    • 1
  • S. Pettersson
    • 1
  1. 1.Department of Urology, Sahlgrenska sjukhusetUniversity of GöteborgGöteborgSweden

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