Serum pattern of parathyroid hormone, calcitonin and calcium following a calcium-rich test meal in patients with recurrent calcium urolithiasis and controls
The metabolism of calcium, parathyroid hormone (PTH) and calcitonin in recurrent idiopathic normo- and hypercalciuric urolithiasis (RCU) is at present far from being resolved. Among the reasons are lacking data on 1) the unclarified nature of intestinal calcium hyperabsorption in patients with idiopathic hypercalciuria (I-HC), 2) the dynamics of serum calcium in response to calcium fluxes into the blood in both normo- and hypercalciuric patients, 3) the dynamics of the associated PTH immunoreactivity, as well as on the suppressibility of the parathyroid glands, as reflected for example by cyclic AMP (cAMP) in urine, 4) the ability of oral calcium to stimulate calcitonin as a protective factor toward nephrocalcinosis (1), and as a potentially hypercalciuric agent (2).
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