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Pathophysiologische Aspekte der koronaren Herzkrankheit

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Herzerkrankungen

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Zusammenfassung

Die Energiegewinnung im Myokard beruht fast ausschließlich auf oxidativen Prozessen. Eine adäquate Myokardfunktion ist daher nur aufrechtzuerhalten, wenn die Sauerstoffversorgung ständig dem jeweiligen Bedarf entspricht. Der im Myoglobin des Myokards gespeicherte Sauerstoff deckt höchstens den O2-Bedarf von 6–8 Schlägen (13). Die myokardiale Sauerstoffextraktion beträgt bereits in Ruhe ca. 75% und kann deshalb im Vergleich zu anderen Organsystemen nicht wesentlich gesteigert werden [Übersicht (2) und (14)]. Somit steht dem Herzen als einzig wirksamer Anpassungsmechanismus bei erhöhtem O2-Bedarf eine Steigerung der Durchblutung zur Verfügung. Jede Störung der Regulationsbreite der Koronardurchblutung beinhaltet daher das potentielle Risiko einer Myokardischämie.

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Authors and Affiliations

  1. Institut für Angewandte Physiologie und Balneologie der Universität, Hermann-Herder-Straße 7, 7800, Freiburg, Germany

    Dr. U. Pohl

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  1. Dr. U. Pohl
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  1. Herz- und Kreislaufzentrum Rotenburg a.d. Fulda, Panoramastraße, 6442, Rotenburg a.d. Fulda, Germany

    F. Loskot

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© 1986 Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt

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Pohl, U. (1986). Pathophysiologische Aspekte der koronaren Herzkrankheit. In: Loskot, F. (eds) Herzerkrankungen. Steinkopff. https://doi.org/10.1007/978-3-642-72395-7_9

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  • DOI: https://doi.org/10.1007/978-3-642-72395-7_9

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-642-72396-4

  • Online ISBN: 978-3-642-72395-7

  • eBook Packages: Springer Book Archive

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