Abstract
Among the pathogenetic factors concerned in calcium oxalate nephrolithiasis, the level of high molecular weight inhibitors such as glycosaminoglycans (GAG) seems to play a significant role (1). On different occasions one research group (2, 3) detected a significantly lower daily GAG output in the urine of stone-formers in comparison to normal subjects. Other investigations failed, however, to confirm these findings (4–6). This might be explained by different population types, different methods or different working conditions in similar methodological contexts. Since urinary GAG are highly heterogeneous with respect to molecular weight and charge density even for a particular type (7), methodological problems appear to be the most probable factor. We thus decided to investigate possible differences between two methods used to characterize GAG excretion.
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References
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© 1980 Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG., Darmstadt
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Marchesini, B., Martelli, A., Buli, P., Brunocilla, E., Tiozzi, E., Spatafora, S. (1980). Evaluating glycosaminoglycan excretion in stone-formers. Are the results method-independent?. In: Gasser, G., Vahlensieck, W. (eds) Pathogenese und Klinik der Harnsteine XI. Fortschritte der Urologie und Nephrologie, vol 23. Steinkopff. https://doi.org/10.1007/978-3-642-72385-8_7
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DOI: https://doi.org/10.1007/978-3-642-72385-8_7
Publisher Name: Steinkopff
Print ISBN: 978-3-7985-0677-0
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