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Fortschritte in der Kardiologie pp 173–180Cite as

Pharmakologische Aspekte der medikamentösen Langzeittherapie

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Part of the book series: Tagung der Deutschen Gesellschaft für Herz- und Kreislaufforschung ((2849,volume 49))

Zusammenfassung

Experimentell pharmakologische Beiträge hinsichtlich der Wirksamkeit von Pharmaka bei täglicher Verabreichung über längere Zeiträume sind im Vergleich zur Überfülle der Berichte über akute Pharmakonwirkungen nur selten in der Literatur vorzufinden. Gründe hierfür liegen vor allem in den methodischen Schwierigkeiten, eine Wirksamkeit an geeigneten Krankheitsmodellen an Tieren anhand geeigneter Parameter über längere Zeiträume hin zu verfolgen. Auch in der klinischen Literatur sind exakte Studien über Langzeiteffekte bei chronischen Erkrankungen vor allem wegen der Notwendigkeit einer ambulanten Durchführung und der damit verbundenen Unsicherheit in der Einhaltung der Untersuchungsbedingungen nur vereinzelt vorzufinden. In letzter Zeit haben die Ergebnisse von Langzeitstudien über die Wirksamkeit von peroral blutzuckersenkenden Stoffen (76) sowie von Antihypertensiva zur Prävention kardiovaskulärer Erkrankungen (5, 37) oder von Auslaßstudien an chronisch digitalisierten Patienten mit chronischer Herzinsuffizienz (8, 28, 40, 41, 49) und schließlich auch die Resultate der „Multiple Risk Factor Intervention“-Studie (59) Zweifel an der Zweckmäßigkeit und Sicherheit von Langzeitpharmakotherapien bei bestimmten chronischen Krankheiten aufkommen lassen.

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  1. Pharmakologisches Institut, der Universität Wien, Währinger Straße 13a, A-1090, Wien IX, Austria

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Kraupp, O. (1983). Pharmakologische Aspekte der medikamentösen Langzeittherapie. In: Schaper, W., Gottwik, M.G. (eds) Fortschritte in der Kardiologie. Tagung der Deutschen Gesellschaft für Herz- und Kreislaufforschung, vol 49. Steinkopff. https://doi.org/10.1007/978-3-642-72371-1_20

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