Combined Treatment with Thiazides and Magnesium in Patients with Recurrent Calcium Oxalate Stone Disease
Thiazides have been extensively used during the last decade to prevent the formation of calcium-containing stones in the urinary tract (Coe 1977; Yendt and Cohanim, 1978). The rationale for this is a reduction in urinary calcium excretion. An increased urinary excretion of magnesium, which may be advantageous in stone prophylaxis, has also been observed (Yendt and Cohanim 1978). However, at least in some patients this effect seems to be transient (Ahlstrand and Tiselius 1981). Furthermore, development of magnesium deficiency during long-term thiazide therapy has been suspected according to observations in patients with cardiac disease (Dyckner and Wester 1978).
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