Abstract
In recent years there have been many reports on the relative potencies of various urinary inhibitors of calcium oxalate crystallization (1-5). Most of these studies, however, have been carried out at low levels of supersaturation using either diluted urine or additives to modify the rates of crystal growth (2, 5) and/or agglomeration (1, 5) of calcium oxalate seed crystals added to the system. More recently, attempts have been made to determine the effects of various urinary constituents using a continuous crystallizer (6), a system involving crystallization at a constant composition (7) and an evaporation system (8). In this study we report on the measurement of the rates of growth and agglomeration of calcium oxalate crystals using both batch and continuous crystallizer systems. The crystals are generated in situ at high levels of supersaturation approximating to those in the urine of recurrent calcium oxalate stone formers.
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References
Robertson, W. G., Peacock, M., Nordin, B. E. C: Inhibitors of the growth and aggregation of calcium oxalate crystals in vitro. Clin. Chim. Acta 43: 31–37 (1973).
Meyer, J. L., Smith, L. H.: Growth of calcium oxalate crystals. II. Inhibition by natural urinary crystal growth inhibitors. Invest. Urol. 13: 36–39 (1975).
Fleisch, H.: Inhibitors and promoters of stone formation. Kidney Int. 13: 361–371 (1978).
Baumann, J. M., Wacker, M.: The direct measurement of inhibitory capacity to crystal growth of calcium oxalate in undiluted urine and in other inhibitor containing solutions. Urol. Res. 8: 171–175 (1980).
Ryall, R. L., Harnett, R. M., Marshall, V. R.: The effect of urine pyrophosphate, citrate, magnesium and glycosaminoglycans on the growth and aggregation of calcium oxalate crystals in vitro. Clin. Chim. Acta 112: 349–356 (1981).
Randolph, A. D., Drach, G. W.: Some measurements of calcium oxalate nucleation and growth rates in urine-like liquors. J. Crystal Growth 53: 195–201 (1981).
Sheehan, M. E., Nancollas, G. H.: Calcium oxalate crystal growth. A new constant composition method for modelling urinary stone formation. Invest. Urol. 17: 446–450 (1980).
Hallson, P. C, Rose, G. A.: A new urinary test for stone “activity”. Br. J. Urol. 50: 442–448 (1978).
Robertson, W. G., Scurr, D. S., Bridge, C. M.: Factors influencing the crystallization of calcium oxalate-critique. J. Crystal Growth 53: 182–194 (1981).
Robertson, W. G., Peacock, M., Nordin, B. E. C: Calcium oxalate crystalluria and urine saturation in recurrent renal stone-formers. Clin. Sci. 40: 365–374 (1971).
Robertson, W. G., Latif, A. B., Scurr, D. S., Caswell, A. M., Drach, G. W., Randolph, A. D.: Inhibitors of calcium oxalate crystallization in urine from stone-formers and normals. In: Proceedings of the Urinary Stone Conference, Singapore (1983).
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© 1984 Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG., Darmstadt
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Robertson, W.G., Scurr, D.S., Latif, A.B. (1984). A Comparison of Inhibitors of the Crystallization of Calcium Oxalate in Two High-Supersaturation Systems. In: Vahlensieck, W., Gasser, G. (eds) Pathogenese und Klinik der Harnsteine X. Fortschritte der Urologie und Nephrologie, vol 22. Steinkopff. https://doi.org/10.1007/978-3-642-72370-4_28
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DOI: https://doi.org/10.1007/978-3-642-72370-4_28
Publisher Name: Steinkopff
Print ISBN: 978-3-7985-0629-9
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