A Comparison of Inhibitors of the Crystallization of Calcium Oxalate in Two High-Supersaturation Systems

  • W. G. Robertson
  • D. S. Scurr
  • A. B. Latif
Part of the Fortschritte der Urologie und Nephrologie book series (2824, volume 22)


In recent years there have been many reports on the relative potencies of various urinary inhibitors of calcium oxalate crystallization (1-5). Most of these studies, however, have been carried out at low levels of supersaturation using either diluted urine or additives to modify the rates of crystal growth (2, 5) and/or agglomeration (1, 5) of calcium oxalate seed crystals added to the system. More recently, attempts have been made to determine the effects of various urinary constituents using a continuous crystallizer (6), a system involving crystallization at a constant composition (7) and an evaporation system (8). In this study we report on the measurement of the rates of growth and agglomeration of calcium oxalate crystals using both batch and continuous crystallizer systems. The crystals are generated in situ at high levels of supersaturation approximating to those in the urine of recurrent calcium oxalate stone formers.


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  1. 1.
    Robertson, W. G., Peacock, M., Nordin, B. E. C: Inhibitors of the growth and aggregation of calcium oxalate crystals in vitro. Clin. Chim. Acta 43: 31–37 (1973).PubMedCrossRefGoogle Scholar
  2. 2.
    Meyer, J. L., Smith, L. H.: Growth of calcium oxalate crystals. II. Inhibition by natural urinary crystal growth inhibitors. Invest. Urol. 13: 36–39 (1975).PubMedGoogle Scholar
  3. 3.
    Fleisch, H.: Inhibitors and promoters of stone formation. Kidney Int. 13: 361–371 (1978).PubMedCrossRefGoogle Scholar
  4. 4.
    Baumann, J. M., Wacker, M.: The direct measurement of inhibitory capacity to crystal growth of calcium oxalate in undiluted urine and in other inhibitor containing solutions. Urol. Res. 8: 171–175 (1980).PubMedCrossRefGoogle Scholar
  5. 5.
    Ryall, R. L., Harnett, R. M., Marshall, V. R.: The effect of urine pyrophosphate, citrate, magnesium and glycosaminoglycans on the growth and aggregation of calcium oxalate crystals in vitro. Clin. Chim. Acta 112: 349–356 (1981).PubMedCrossRefGoogle Scholar
  6. 6.
    Randolph, A. D., Drach, G. W.: Some measurements of calcium oxalate nucleation and growth rates in urine-like liquors. J. Crystal Growth 53: 195–201 (1981).CrossRefGoogle Scholar
  7. 7.
    Sheehan, M. E., Nancollas, G. H.: Calcium oxalate crystal growth. A new constant composition method for modelling urinary stone formation. Invest. Urol. 17: 446–450 (1980).PubMedGoogle Scholar
  8. 8.
    Hallson, P. C, Rose, G. A.: A new urinary test for stone “activity”. Br. J. Urol. 50: 442–448 (1978).PubMedCrossRefGoogle Scholar
  9. 9.
    Robertson, W. G., Scurr, D. S., Bridge, C. M.: Factors influencing the crystallization of calcium oxalate-critique. J. Crystal Growth 53: 182–194 (1981).CrossRefGoogle Scholar
  10. 10.
    Robertson, W. G., Peacock, M., Nordin, B. E. C: Calcium oxalate crystalluria and urine saturation in recurrent renal stone-formers. Clin. Sci. 40: 365–374 (1971).PubMedGoogle Scholar
  11. 11.
    Robertson, W. G., Latif, A. B., Scurr, D. S., Caswell, A. M., Drach, G. W., Randolph, A. D.: Inhibitors of calcium oxalate crystallization in urine from stone-formers and normals. In: Proceedings of the Urinary Stone Conference, Singapore (1983).Google Scholar

Copyright information

© Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG., Darmstadt 1984

Authors and Affiliations

  • W. G. Robertson
    • 1
  • D. S. Scurr
    • 1
  • A. B. Latif
    • 1
  1. 1.MRC Mineral Metabolism UnitThe General InfirmaryLeedsGreat Britain

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