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Spontanverlauf der Kollagenosen

  • K. Helmke
Conference paper

Zusammenfassung

Ein wesentliches, gemeinsames Charakteristikum der verschiedenen Krankheitsbilder, die unter dem Begriff der Kollagenosen zusammengefaßt werden, ist, daß sie mit einer Ausnahme alle Spontanverlaufe zeigen können, die vorstellbar sind: Sowohl der rasche, therapeutisch nicht zu beeinflussende tödliche Verlauf wie auch ein jahrelang sich hinziehendes, schubweise sich verschlechterndes Krankheitsbild ist möglich; zum anderen paßt aber auch eine jahrelange Remission nach akuter, lebensbedrohlicher Erkrankung in diesen Rahmen, ebenso wie ein nur mildes, kurz aufflammendes Krankheitsbild, welches nach gering dosierter medikamentöser Therapie in die komplette Remission kommt und ohne jegliche Medikation über Jahre inaktiv bleibt (Abb. 1). — Nur ein Krankheitsverlauf läßt sich bis heute noch nicht dieser Krankheitsgruppe zuordnen: die sichere, entweder spontan oder therapeutisch induzierte Ausheilung. Wenngleich sehr viele gerade der milden Verlaufsformen über Jahre bis Jahrzehnte beschwerdefrei und ohne Krankheitssymtomatik und Therapie sind, so daß sie eigentlich als geheilt bzw. gesund angesehen werden können, lehrt doch die Erfahrung, daß es auch nach solch langer Ruhepause zu einem plötzlichen erneuten Ausbruch der Erkrankung kommen kann. Diese Unsicherheit ist bedingt durch die Unkenntnis der genauen Ätiologie und — trotz vieler wichtiger und weiterführender Forschungsergebnisse auf diesem Feld — auch weitgehend der Pathogenese dieser Erkrankungen (22, 52, 61, 95, 113).

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Copyright information

© Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt 1983

Authors and Affiliations

  • K. Helmke
    • 1
  1. 1.Medizinische Klinik III und Poliklinik der Justus-Liebig-UniversitätGießenDeutschland

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