Prevention of infected urinary stones by a new drug: The propionohydroxamic acid (PHA)
It’s well known the mechanism whereby the enzyme urease produced by urea splitting bacteria, causes ureolysis and, as an end result, the supersaturation of urine with struvite and carbonato-apatite crystals (1). Another cause of the formation of renal stones may be the direct action of the inflammatory process on the urinary tract, thus causing an increase in mucoproteins and hence an increase in the likelihood for the nucleation of struvite and carbonate-apatite crystals.
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