Prevention of infected urinary stones by a new drug: The propionohydroxamic acid (PHA)

  • Aldo Martelli
  • P. Buli
  • E. Brunocilla
Conference paper
Part of the Fortschritte der Urologie und Nephrologie book series (2824, volume 20)


It’s well known the mechanism whereby the enzyme urease produced by urea splitting bacteria, causes ureolysis and, as an end result, the supersaturation of urine with struvite and carbonato-apatite crystals (1). Another cause of the formation of renal stones may be the direct action of the inflammatory process on the urinary tract, thus causing an increase in mucoproteins and hence an increase in the likelihood for the nucleation of struvite and carbonate-apatite crystals.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Griffith D.P., Musher D.M.: Proceedings of the International Colloquium on Urinary Stones. Ed. by B. Finlayson and W.C. Thomas-in press.Google Scholar
  2. 2.
    Griffith D.P., Musher D.M. and Campbell J.W.: Invest. Urol. 11: 234 (1973).PubMedGoogle Scholar
  3. 3.
    Griffith D.P., Musher D.M.: Urology, 5: 299 (1975).CrossRefGoogle Scholar
  4. 4.
    Griffith D.P., Musher D.M.: Invest. Urol., 11: 228 (1973).PubMedGoogle Scholar
  5. 5.
    Fishbein W.N., Daly J. and Steeter C.L.: Anal. Biochem., 28: 13 (1969).PubMedCrossRefGoogle Scholar
  6. 6.
    Fishbein W.N., Biochem. Med., 1: 111 (1970).CrossRefGoogle Scholar
  7. 7.
    Kreybig Th. von, Preussman R. und Schmidt W., Arzneim. Forsch., 18: 645 (1968).Google Scholar

Copyright information

© Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt 1982

Authors and Affiliations

  • Aldo Martelli
    • 1
  • P. Buli
    • 1
  • E. Brunocilla
    • 1
  1. 1.Department of urologyUniversity of BolognaBolognaItaly

Personalised recommendations