Advertisement

Renal handling of urate in renal stone patients during treatment with thiazides

  • S. Ljunghall
  • U. Backman
  • B. G. Danielson
  • B. Fellström
  • G. Johannsson
  • B. Wikström
Conference paper
Part of the Fortschritte der Urologie und Nephrologie book series (2824, volume 20)

Abstract

It is well known that thiazide treatment raises the serum urate levels (1). It has also been reported that the urinary excretion of urate is enhanced during long-term thiazide therapy (2). Such an increase might be deleterious for stone-prone individuals as a high urinary urate will reduce the inhibitory capacity of the urine and possibly also stimulate heterogenous nucleation of calcium oxalate crystallization.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Healey, L.A., Magid, G.J., and Decker, J.L.: Uric acid retention due to hydrochlorothiazide. N. Engl. J. Med., 261: 1358 (1959).PubMedCrossRefGoogle Scholar
  2. 2.
    Pak, C.Y.C., Tolentino, R., Stewart, A., and Galosy, R.A.: Enhancement of renal excretion of uric acid during long-term thiazide therapy. Invest. Urol., 16: 191 (1978).PubMedGoogle Scholar
  3. 3.
    Lang. F., Greger, R., and Deetjen, P.: Effect of diuretics on uric acid metabolism and excretion. In Diuretics in research and clinics, pp. 213–224, W. Siegenthaler, R. Beckerhoff, and W. Vetter (Editors). Georg Thieme Publ. Stuttgart, 1977.Google Scholar
  4. 4.
    Backman, U., Danielson, B.G., Johansson, G., Ljunghall, S., and Wikström, B.: Incidence and clinical importance of renal tubular defects in recurrent renal stone formers. Nephron, 25: 96 (1980).PubMedCrossRefGoogle Scholar
  5. 5.
    Weinman, E.J., Eknoyan, G., and Suki, WN.: The invluence of the extracellular fluid volume on the tubular reabsorption of uric acid. J. Clin. Invest., 55: 283 (1975).PubMedCrossRefGoogle Scholar
  6. 6.
    Ayvazian, I.H., and Ayvazian, F.L.: A study of the hyperurecemia induced by hydrochlorothiazide and acetazolamide separately and in combination. J. Clin. Invest., 40: 1961 (1961).PubMedCrossRefGoogle Scholar

Copyright information

© Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt 1982

Authors and Affiliations

  • S. Ljunghall
    • 1
  • U. Backman
    • 1
  • B. G. Danielson
    • 1
  • B. Fellström
    • 1
  • G. Johannsson
    • 1
  • B. Wikström
    • 1
  1. 1.Department of Internal MedicineUniversity HospitalUppsalaSchweden

Personalised recommendations