Renal handling of urate in renal stone patients during treatment with thiazides
It is well known that thiazide treatment raises the serum urate levels (1). It has also been reported that the urinary excretion of urate is enhanced during long-term thiazide therapy (2). Such an increase might be deleterious for stone-prone individuals as a high urinary urate will reduce the inhibitory capacity of the urine and possibly also stimulate heterogenous nucleation of calcium oxalate crystallization.
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- 3.Lang. F., Greger, R., and Deetjen, P.: Effect of diuretics on uric acid metabolism and excretion. In Diuretics in research and clinics, pp. 213–224, W. Siegenthaler, R. Beckerhoff, and W. Vetter (Editors). Georg Thieme Publ. Stuttgart, 1977.Google Scholar