Abstract
It is well known that thiazide treatment raises the serum urate levels (1). It has also been reported that the urinary excretion of urate is enhanced during long-term thiazide therapy (2). Such an increase might be deleterious for stone-prone individuals as a high urinary urate will reduce the inhibitory capacity of the urine and possibly also stimulate heterogenous nucleation of calcium oxalate crystallization.
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References
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© 1982 Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt
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Ljunghall, S., Backman, U., Danielson, B.G., Fellström, B., Johannsson, G., Wikström, B. (1982). Renal handling of urate in renal stone patients during treatment with thiazides. In: Gasser, G., Vahlensieck, W. (eds) Pathogenese und Klinik der Harnsteine IX. Fortschritte der Urologie und Nephrologie, vol 20. Steinkopff. https://doi.org/10.1007/978-3-642-72360-5_68
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DOI: https://doi.org/10.1007/978-3-642-72360-5_68
Publisher Name: Steinkopff
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