The interaction of urinary inhibitors with crystals
It has been proposed that hyperuricosuria may promote calcium oxalate stone formation. One of the suggested mechanisms is an interference between urate microcrystals and naturally occurring macromolecular inhibitors of crystal growth and aggregation (1). Furthermore, it has been shown in vitro that sodium urate crystals may absorb heparin, a potent inhibitor of calcium oxalate crystallisation (2). As heparin is not excreted in human urine other than in minute amounts we decided to study the interference between naturally occurring urinary inhibitors and various crystals.
Unable to display preview. Download preview PDF.
- 4.Schrier, E. F., Lee, K. E., Robin, J. L., Werness, P. G., Smith, L. H. (1978). Macro- molecular inhibitors of calcium oxalate crystal growth and aggregation in the urine. In: Oxalate in Human Biochemistry and Clinical Pathology, pp. 22–27. Eds. Rose, G. A., Robertson, W. G., Watts, R. W. E.: Proceedings from an International Symposium, The Wellcome Foundation.Google Scholar
- 7.Comper, W. D., Laurent, T. C. (1978). Physiological function of connective tissue ply saccharides. Physiological Reviewes 58, 255–315.Google Scholar