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Oxidation and Reduction of Lysalal by Soluble Aorta Fractions

  • J. H. Wissler
  • E. Logemann
Conference paper
Part of the Verhandlungen der Deutschen Gesellschaft für Kreislaufforschung book series (2849, volume 44)

Zusammenfassung

Substitued lysalal (L-α-Amino-adipate-δ-semialdehyde) represents the cross- linking agent in the formation of desmosine, isodesmosine and Lysinnorleucin as bridges in mature elastin (Fig. 1). To elucidate possible regulatory mechanisms enzymatically Controlling the formation of crosslinks in elastin and maintaining the structural equilibrium in its turnover, we synthetized D,L-lysalal according to Fig. 2 by the method of Aspen and Meister (Biochemistry 1, 600, 1962). The resulting anhydrous product, Δ1-piperideine-ö-carboxylate is in equilibrium with the free and hydrated aldehyde group of lysalal (Fig. 3). We found that soluble aortic extracts are capable to oxidise or to reduce this aldehyde with NAD (NADP) and NADPH, respectively (Fig. 4).

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Copyright information

© Dr. Dietrich Steinkopff Verlag GmbH & Co. KG Darmstadt 1978

Authors and Affiliations

  • J. H. Wissler
    • 1
  • E. Logemann
    • 1
  1. 1.Max-Planck-Institut für Exp. Kardiologie, Arbeitsgruppe BiochemieBad Nauheim Chemisches Institut der Universität FreiburgGermany

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