Komplement pp 210-239 | Cite as

In vivo-Störungen des Komplement-Systems

  • Klaus Rother

Zusammenfassung

Selbst bei stürmisch verlaufenden Immunreaktionen erreicht der Verbrauch an C-Aktivität nur selten Größenordnungen, die sich in einer signifikanten Depression des hämolytischen Gesamt-C-Titers niederschlagen. Eine Ausnahme machen wohl nur die Nephritiden, bei denen wegen der Größe der betroffenen Oberflächen ausnahmsweise große Mengen von Ag, Ak und C reagieren, was detailliert am Beispiel der Masugi-Nephritis bei H3 diskutiert wird. Beim Menschen beträgt z. B. die gesamte innere Oberfläche der Glomerulum-Kapillaren 1,5 m2 (!) bei einer Gesamtlänge von 25 km (Bargmann 1962). Die gleichmäßige Auskleidung dieser riesigen Oberfläche mit Ak-gebundenem C bei Nephritis läßt sich auf Abb. 71 erkennen. Es leuchtet ohne weiteres ein, daß sich die Absorption derartig großer Mengen in einem Schwund der zirkulierenden C-Menge widerspiegeln muß. Dies gilt sowohl für die experimentellen Glomerulonephritiden nach dem Verfahren von Masugi als auch für die menschlichen Nephritiden und die Nephritiden mit nephrotischen Verläufen, wie sie besonders bei Kindern auftreten. Wie nicht anders zu erwarten, führt die intrarenale Ag-Ak-Reaktion zur Aktivierung des C-Systems unter Einbeziehung aller Komponenten (vgl. H3) und folglich läßt sich der periphere Schwund des C auch bei Titration der Einzelkomponenten erfassen. Der C-Schwund ist bei dieser Krankheitsgruppe so charakteristisch, daß sogar vorgeschlagen wurde, ihn zur Beurteilung der Intensität der Immunreaktion und damit zur Beurteilung der Prognose der Nephritis zu benutzen (Lange, Wasserman und Slobody 1960).

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Copyright information

© Dr. Dietrich Steinkopff Verlag, Darmstadt 1974

Authors and Affiliations

  • Klaus Rother
    • 1
  1. 1.Univ.-Institut für Immunologie und SerologieHeidelbergGermany

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