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Topography and Cellular Localization of reelin mRNA and Protein Expression During Brain Development

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Book cover The Reeler Mouse as a Model of Brain Development

Abstract

In their initial description of the reelin gene, D’Arcangelo et al. (1995) noted heavy reelin mRNA expression in Cajal-Retzius neurons of the marginal zone (MZ) as well as in external granule cells of the cerebellum and a few other structures. A systematic survey of reelin mRNA expression during mouse brain development was subsequently carried out by Schiffmann et al. (1997), using a reelin-specific antisense oligonucleotide labeled with 35S, as well as DIG-labeled riboprobes. The identification of embryonic mouse brain nuclei was carried out using the embryonic rat brain atlas of Altman and Bayer (1995). A summary of the expression patterns found at the various stages studied is provided in Table 2.

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© 1998 Springer-Verlag Berlin Heidelberg

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Lambert de Rouvroit, C., Goffinet, A.M. (1998). Topography and Cellular Localization of reelin mRNA and Protein Expression During Brain Development. In: The Reeler Mouse as a Model of Brain Development. Advances in Anatomy Embryology and Cell Biology, vol 150. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72257-8_3

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  • DOI: https://doi.org/10.1007/978-3-642-72257-8_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-64674-7

  • Online ISBN: 978-3-642-72257-8

  • eBook Packages: Springer Book Archive

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