Section 3.1 will show that the lesion model used, i.e., the resection of 10 mm of the infratemporal portion of the facial nerve, fully inhibits post-operative axonal sprouting and causes a delayed, but significant loss of neurons in the facial nucleus.
Section 3.2 provides evidence that the neuronal death caused by resection of the facial nerve does not lead to a breakdown of the blood-brain barrier and that there occurs no passage of unprimed lymphocytes into the brain tissue.
Section 3.3 describes the different patterns of cell labeling with the permanent tracer Fluoro-Gold (FG) after its intramuscular, intravenous, and intracerebroventricular (ICV) injection.
Section 3.4 covers our quantitative and qualitative estimates on the time course of existence and migration of FG-labeled neuronophages.
Section 3.5 shows the time course of expression of immune related antigens by FG-labeled neuronophages. It provides evidence that perivascular cells migrate from the perivascular space into perineuronal position and, like the microglia, carry out neuronophagia. Finally, Sect. 3.5 shows that after neuronophagia, perivascular cells — but not microglia — return to the perivascular space.
KeywordsPermeability Migration Toxicity Sine Eosin
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