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Familienangehörige Schizophrener als Risikopersonen: Familiengenetik und neuere molekulargenetische Ansätze

  • W. Maier
  • M. Rietschel
  • D. Lichtermann
  • M. Linz
Conference paper
Part of the Bayer-ZNS-Symposium book series (BAYERZNS, volume 13)

Zusammenfassung

Als Risikofaktoren für eine schizophrene Erkrankung gelten seit langem die familiäre Häufung und die teilweise genetische Determination, der jedoch kein bekannter monogener Erbgang zugrunde liegt. Statt dessen wird die Beteiligung mehrerer Gene und deren Interaktion mit nichtgenetischen Umweltfaktoren angenommen. Familiengenetisch handelt es sich bei der Schizophrenie um einen unscharf begrenzten, inhaltlich heterogenen Phänotyp, der aus der Kombination verschiedener, genetisch unterschiedlich determinierter neurokognitiver Dysfunktionen resultiert. Die variable Expression erschwert die Identifikation der relevanten Genmutationen erheblich. Trotz dieser und anderer Schwierigkeiten ist es durch die seit ca. zehn Jahren verfügbaren molekulargenetischen Methoden möglich geworden, auf Genomebene nach Suszeptibilitätsgenen für komplexe Erkrankungen zu suchen und die einzelnen Genmutanten auf ihre ursächliche Rolle bei der Entstehung genetisch determinierter Störungen hin zu analysieren. Dabei wird ausführlich auf die Strategien der Kopplungsanalyse und der Assoziationsuntersuchung, ihre jeweiligen Vorund Nachteile sowie die bisher mit ihrer Hilfe gewonnenen Erkenntnisse eingegangen.

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© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • W. Maier
  • M. Rietschel
  • D. Lichtermann
  • M. Linz

There are no affiliations available

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