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Testosterone pp 423-436 | Cite as

Percutaneous dihydrotestosterone treatment

  • Gilbert Schaison
  • Béatrice Couzinet

Abstract

The aim of hormone replacement therapy is to obtain normal physiologic levels of sex steroids.

Keywords

Percutaneous Absorption Testosterone Undecanoate Male Hypogonadism Plasma Estradiol Level Aromatase Deficiency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ahmed R, Boucher A, Manni A, Santen R, Bartholomew M, Demers L (1988) Transdermal testosterone therapy in the treatment of male hypogonadism. J Clin Endocrinol Metabol 66: 546–551CrossRefGoogle Scholar
  2. Bals-Pratsch M, Knuth UA, Yoon YD, Nieschlag E (1986) Transdermal testosterone substitution therapy for male hypogonadism. Lancet 25: 943–945CrossRefGoogle Scholar
  3. Behre HM, Nieschlag E (1992) Testosterone buciclate (20 Act-1) in hypogonadal men: pharmacokinetics and pharmacodynamics of the new long acting androgen ester. J Clin Endocrinol Metabol 75: 1204–1210CrossRefGoogle Scholar
  4. Behre HM, Kliesch S, Leifke E, Link TM, Nieschlag E (1997) Long term effect of testosterone therapy on bone mineral density in hypogonadal men. J Clin Endocrinol Metabol 82: 2386–2390CrossRefGoogle Scholar
  5. Bhasin S, Swerdloff RS, Steiner B, Peterson MA, Meridores T, Galmirini M, Pandian MR, Goldberg R, Berman N (1992) A biodegradable testosterone microcapsule formulation provides uniform eugonadal levels of testosterone for 10–11 weeks in hypogonadal men. J Clin Endocrinol Metabol 74: 75–83CrossRefGoogle Scholar
  6. Bhasin S, Bremner WJ (1997) Emerging issues in androgen replacement therapy. J Clin Endocrinol Metabol 82: 3–8CrossRefGoogle Scholar
  7. Bulard J, Mowszowicz I, Schaison G (1987) Increased aromatase activity in pubic skin fibroblasts from patients with isolated gynecomastia. J Clin Endocrinol Metabol 64: 618–623CrossRefGoogle Scholar
  8. Cantril JA, Dewis P, Large DM, Newman M, Anderson DC (1984) Which testosterone replacement therapy? Clin Endocrinol (Oxf), 21: 97–107CrossRefGoogle Scholar
  9. Carani C, Qin K, Simoni M, Faustini-Fustini M, Serpente S, Boyd J, Korach KS, Simpson ER (1997) Effect of testosterone and estradiol in a man with aromatase deficiency. N Engl J Med 337: 91–95PubMedCrossRefGoogle Scholar
  10. Delanoe D, Fougeyrollas B, Meyer L, Thonneau P (1984) Androgenization of female partners of men on medroxyprogesterone acetate/percutaneous testosterone contraception. Lancet 4: 276–277CrossRefGoogle Scholar
  11. Delignieres B, Morville R (1980) Treatment of male hypogonadism by topical administration of androgens. Percutaneous absorption of steroids. P Mauvais-Jarvis, CFH/Vickers, J Wepierre (eds) Academic Press, pp 273–283Google Scholar
  12. Fiet J, Morville R, Chemama D, Vilette JM, Gourmel B, Brerault JL, Dreux C (1982) Percutaneous absorption of 5a dihydrotestosterone in man. I. Plasma androgen and gonadotropin levels in normal adult men after percutaneous administration of 5a didydrotestos- terone. Int J Androl 5: 586–594PubMedCrossRefGoogle Scholar
  13. Findlay JC, Place VA, Snyder PJ (1989) Treatment of primary hypogonadism in men by the transdermal administration of testosterone. J Clin Endocrinol Metab 68: 369–373PubMedCrossRefGoogle Scholar
  14. Grinspoon S, Corcoran C, Lee K, Burrows B, Hubbard J, Katznelson L, Walsh M, Guccione A, Cannan J, Heller H, Basgoz N, Klibanski A (1996) Loss of lean body and muscle mass correlates with androgen levels in hypogonadal men with acquired immunodeficiency syndrome and wasting. J Clin Endocrinol Metab 81: 4051–4058PubMedCrossRefGoogle Scholar
  15. Jayle MF (1980) In memoriam. Percutaneous absorption of steroids. P Mauvais-Jarvis, CFH Vickers, J Wepierre (eds) Academic Press, 273–283Google Scholar
  16. Katz MD, Kligman I, Cai LQ, Zhu YS, Fratianni CM, Zervoudakis I, Rosenwaks Z, Imperato-McGinley J (1997) Paternity by intrauterine insemination with sperm from a man with 5a-reductase 2 deficiency. N Engl J Med 336: 994–997PubMedCrossRefGoogle Scholar
  17. Korenman S, Viosca S, Garza D, Guralnik M, Place V, Campbell P, Davis S (1987) Androgen therapy of hypogonadal men with transscrotal testosterone systems. Am J Med 83: 471–478PubMedCrossRefGoogle Scholar
  18. Kuhn JM, Roca R, Laudat MH, Rieu M, Luton JP, Bricaire H (1983) Studies on the treatment of idiopathic gynaecomastia with percutaneous dihydrotestosterone. Clin Endocrinol 19: 513–520CrossRefGoogle Scholar
  19. Kuhn JM, Rieu M, Laudat MH, Forest M, Pugeat M, Bricaire H, Luton JP (1984) Effects of 10 days administration of percutaneous dihydrotestosterone on the pituitary-testicular axis in normal men. J Clin Endocrinol Metab 58: 231–235PubMedCrossRefGoogle Scholar
  20. Lindzey J, Wetsel WC, Stoker T, Cooper R, Couse JF, Korach KS (1997) Steroid regulation of hypothalamic GnRH and serum LH levels in male estrogen receptor knock out mice. The Endocrine Society 79th meeting. Minneapolis, MN: Abstract OR 16–3Google Scholar
  21. Meikle AW, Mazer NA, Moellmer JF, Stringham JD, Tolman KG, Sanders SW, Odell WD (1992) Enhanced transdermal delivery of testosterone across the nonscrotal skin produces physiological concentrations of testosterone and its metabolites in hypogonadal men. J Clin Endocrinol Metab 74: 623–628PubMedCrossRefGoogle Scholar
  22. Moore N, Paux G, Noblet C, Andrejak M (1988) Spouse-related drug side-effects. Lancet 27: 468–469CrossRefGoogle Scholar
  23. Moore RJ, Gazak JM, Quebbeman JF, Wilson JD (1979) Concentration of dihydrotestosterone and 3a-androstanediol in naturally occurring and androgen-induced prostatic hyperplasia in the dog. J Clin Invest 64: 1003–1009PubMedCrossRefGoogle Scholar
  24. Morishima A, Grumbach MM, Simpson ER, Fisher C, Qin K (1995) Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. J Clin Endocrinol Metab 80: 3689–3698PubMedCrossRefGoogle Scholar
  25. Schaison G, Renoir M, Lagoguey M, Mowszowicz I (1980) On the role of dihydrostestoster- one in regulating luteinizing hormone secretion in man. J Clin Endocrinol Metab 51: 1133–1137PubMedCrossRefGoogle Scholar
  26. Sitruk-Ware R (1989) Transdermal delivery of steroids. Contraception 39: 1–191PubMedCrossRefGoogle Scholar
  27. Smith EP, Boyd J, Frank GR, Takahashi H, Cohen RM, Specker B, Williams TC, Lubahn DB, Korach KS (1994) Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med 331: 1056–1061PubMedCrossRefGoogle Scholar
  28. Snyder PJ, Lawrence DA (1980) Treatment of male hypogonadism with testosterone en-anthate. J Clin Endocrinol Metab 51: 1335–1339PubMedCrossRefGoogle Scholar
  29. Sokol RZ, Palacios A, Campfield LA, Saul C, Swerdloff RS (1982) Comparison of the kinetics of injectable testosterone in eugonadal and hypogonadal men. Fertil Steril 37: 425–430PubMedGoogle Scholar
  30. Spark R, Brewster SE, Libman H, Dezube BJ (1997) Dihydrotestosterone gel: a novel androgen for AIDS wasting syndrome. The Endocrine Society 79th meeting. Minneapolis, MN: Abstract PI–319Google Scholar
  31. Veldhuis JD, Rogol AD, Samojlik E, Ertel MH (1984) Role of endogenous opiates in the expression of negative feed back actions of androgens and estrogen on pulsatile properties of luteinizing-hormone secretion in man. J Clin Invest 74: 47–55PubMedCrossRefGoogle Scholar
  32. Vermeiden A, Deslypere JP (1985) Long-term transdermal dihydrotestosterone therapy: effects on pituitary gonadal axis and plasma lipoproteins. Maturitas 7: 281–287CrossRefGoogle Scholar
  33. von Eckardstein A, Kliesch S, Nieschlag E, Chirazi A, Assmann G, Behre HM (1997) Suppression of endogenous testosterone in young men increases serum levels of high density lipoprotein subclass lipoprotein 11 and lipoprotein (a). J Clin Endocrinol Metabol 82: 3367–3372CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • Gilbert Schaison
  • Béatrice Couzinet

There are no affiliations available

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