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Tumornekrosefaktor-α (TNF-α) Gen-Polymorphismus bei chirurgischen Intensivpatienten mit SIRS

Tumor necrosis factor alpha gene polymorphism in surgical intensive care patients with SIRS

  • Conference paper
Chirurgisches Forum ’98

Part of the book series: Langenbecks Archiv für Chirurgie ((FORUMBAND,volume I/98))

Zusammenfassung

Das Tumornekrosefaktor-Gen liegt im MHC-Bereich (Major Histocompatibility Complex) auf Chromosom 6 zwischen 6p21.1 und 6p21.3. Die Promotorregion hat verschiedene Bindungsstellen. Bis heute sind 5 Mikrosatelliten im TNF Lokus bekannt. In der TNF Promotorregion wurde ein G/A-Austausch in Position −308 (TNF1 und TNF2) und −238 beschrieben. TNF2 ist die seltenere Variante und scheint mit einer höheren TNF Produktion assoziiert zu sein [1].

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Literatur

  1. Rink L, Kirchner H (1996) Recent Progress in the Tumor Necrosis Factor-α Field. Int Arch Allergy Immunol 111:199–209

    Article  PubMed  CAS  Google Scholar 

  2. Strieter RM, Kunkel SL, Bone RC (1993) Role of tumor necrosis factor-alpha in disease states and inflammation. Crit Care Med 21:S447–S463

    Article  PubMed  CAS  Google Scholar 

  3. Pociot F, Briant L, Jongeneel CV, Molving J, Worsaae H,Abbal M, Thomsen M, Nerup J, Cambon-Thomsen A (1993) Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF-alpha and TNF-beta by human mononuclear cells: a possible link to insulin-dependent diabetes melitus. Eur J Immunol 23:224–231

    Article  PubMed  CAS  Google Scholar 

  4. Wilson AG, di Giovine FS, Duff GW (1992) Single base polymorphyism in the human Tumour Necrosis Factor (TNF) alpha gene detectable by Ncol restriciton of PCR product. Hum Mol Gen 1:353–355

    Article  PubMed  CAS  Google Scholar 

  5. Barthlen W, Stadler J, Lehn NL, Miethke T, Bartels H, Siewert JR (1994) Serum levels of end products of nitric oxide synthesis correlate positively with tumor necrosis factor a and negatively with body temperature in patients with postoperative abdominal sepsis. Shock 2:398–401

    Article  PubMed  CAS  Google Scholar 

  6. Cavaillon JM (1995) Controversies surrounding current therapies for sepsis syndrome. Bull Inst Pasteur 93:21–41

    Article  CAS  Google Scholar 

  7. Schroder J, Stuber F, Gallati H, Schade FU, Kremer B (1995) Pattern of soluble TNF receptors I and II in sepsis. Infection 23:143–148

    Article  PubMed  CAS  Google Scholar 

  8. Stüber F, Petersen M, Bokelmann F, Schade U (1996) A genomic polymorphism within the tumor necrosis factor locus influences plasma tumor necrosis factor-a concentrations and outcome in patients with severe sepsis. Crit Care Med 24:381–384

    Article  PubMed  Google Scholar 

  9. McGuire W, Hill AV, Allsopp CE, Greenwood BM, Kwiatkowski D (1994) Variation in the TNFalpha promoter region associated with susceptibility to cerebral malaria. Nature 371:508–510

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Klinik für Allgemein- und Unfallchirurgie, Deutschland

    K. Dumon, C. Roßbach, W. Groß-Weege, P. E. Goretzki & H. D. Röher

  2. Labor für experimentelle Hämatologie, Klinik für pädiatrische Onkologie und Hämatologie, Deutschland

    V. Gorelov

  3. Immunologisches Labor der Klinik für Transfusionsmedizin, Heinrich-Heine Universität, Moorenstraße 5, 40225, Düsseldorf, Deutschland

    B. Harms & E. M. Schneider

Authors
  1. K. Dumon
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  2. C. Roßbach
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  3. B. Harms
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  4. V. Gorelov
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  5. W. Groß-Weege
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  6. E. M. Schneider
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  7. P. E. Goretzki
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  8. H. D. Röher
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Editor information

Editors and Affiliations

  1. Chirurgischen Universitätsklinik Zentrum für Chirurgie, Kirschnerstr. 1 (INF 110), 69120, Heidelberg, Deutschland

    Ch. Herfarth (Geschäftsführender Direktor) (Geschäftsführender Direktor)

  2. Zentrum Operative Medizin I, Philipps-Universität, Baldingerstraße, 35043, Marburg, Deutschland

    M. Rothmund (Leiter der Klinik für Allgemeinchirurgie) (Leiter der Klinik für Allgemeinchirurgie)

  3. Deutschen Gesellschaft für Chirurgie, Steinhölzle 16, 89198, Westerstetten, Deutschland

    W. Hartel (Generalsekretär) (Generalsekretär)

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© 1998 Springer-Verlag Berlin Heidelberg

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Dumon, K. et al. (1998). Tumornekrosefaktor-α (TNF-α) Gen-Polymorphismus bei chirurgischen Intensivpatienten mit SIRS. In: Herfarth, C., Rothmund, M., Hartel, W. (eds) Chirurgisches Forum ’98. Langenbecks Archiv für Chirurgie, vol I/98. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72182-3_82

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  • DOI: https://doi.org/10.1007/978-3-642-72182-3_82

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-64277-0

  • Online ISBN: 978-3-642-72182-3

  • eBook Packages: Springer Book Archive

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