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Die Rolle der Apoptose in der Toleranzinduktion nach Leber- und Leber/Dünndarmtransplantation

Role of apoptosis for tolerance-induction after liver- and liver/small bowel transplantation

  • Conference paper
Chirurgisches Forum ’98

Part of the book series: Langenbecks Archiv für Chirurgie ((FORUMBAND,volume I/98))

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Zusammenfassung

Tierexperimentell kann durch alleinige Lebertransplantation spezifische Toleranz induziert werden [1]. Gleichzeitig wird dadurch die Akzeptanz weiterer Organtransplantate verbessert. Dies ist tierexperimentell für Niere [2], Pankreas [3] und Dünndarm [4] erwiesen Klinisch wird dies aufgrund einer geringeren Inzidenz chronischer Abstoßungen nach kombinierter Leber/Dünndarmtransplantation vermutet [5]. Ziel dieser Studie ist es, die zelluläre Grundlage beider Mechanismen zu evaluieren.

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Literatur

  1. Engemann R (1993) Orthotopic liver transplantation in the rat. Langenbecks Arch Chir 378:66–67

    Article  PubMed  CAS  Google Scholar 

  2. Rasmussen A, Davies HS, Jamieson NV, Evans DB, Caine RY (1995) Combined transplantation of liver and kidney from the same donor protects the kidney from rejection and improves kidney graft survival. Transplantation 59:919–921

    PubMed  CAS  Google Scholar 

  3. Caine RY, Sells RA, Marshall VC Millard PR, Herbertson BM, Hadjiyannakis EJ (1972) Multiple organ grafts in pigs: technique and results of pancreatic, hepatic, cardiac, and renal allografts. Brit J Surg 59:969–977

    Article  Google Scholar 

  4. Murase N, Demitris J, Matsuzaki T, Yagihashi A, Todo S, Fung J, Starzl TE (1991) Long survival in rats after multivisceral versus isolated small bowel allotransplantation under FK506. Surgery 110:87–98

    PubMed  CAS  Google Scholar 

  5. Grant D (1996) Current results of intestinal transplantation. Lancet 347:1801–1803

    Article  PubMed  CAS  Google Scholar 

  6. Stalder T and Hahn S, Erb P (1994) Fas antigen is the major target of CD4+ Tcell-mediated cytotoxicity. J Immunol 152:1127–1133

    PubMed  CAS  Google Scholar 

  7. Qian S, Lu L, Fu F, Li Y, Li W, Starzl TE, Fung JJ, Thomson AW (1997) Apoptosis within spontaneously accepted mouse liver allografts. J Immunol 158:4654–4661

    PubMed  CAS  Google Scholar 

  8. Lu L, Qian S, Hershberger PA, Rudert WA, Lynch DH, Thomson AW (1997) Fas Ligand (CD 95L) and B7 expression on dendritic cells provide counter-regulatory signals for T cell survival and proliferation. J Immunol 158:5676–5684

    PubMed  CAS  Google Scholar 

  9. Zavazava N, Krönke M (1996) Soluble HLA class I molecules induce apoptosis in allogenic cytotoxic T lymphocytes. Nature Medicine 2:1005–1010

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Chirurgische Universitätsklinik, Josef-Schneider Str. 2, D-97080, Würzburg, Deutschland

    Dr. D. Meyer, H.-J. Gassel & A. Thiede

  2. Experimentelle Transplantations-Immunologie, Josef-Schneider Str. 2, D-97080, Würzburg, Deutschland

    Ch. Otto & K. Ulrichs

Authors
  1. Dr. D. Meyer
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  2. Ch. Otto
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  3. H.-J. Gassel
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  4. K. Ulrichs
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  5. A. Thiede
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Editor information

Editors and Affiliations

  1. Chirurgischen Universitätsklinik Zentrum für Chirurgie, Kirschnerstr. 1 (INF 110), 69120, Heidelberg, Deutschland

    Ch. Herfarth (Geschäftsführender Direktor) (Geschäftsführender Direktor)

  2. Zentrum Operative Medizin I, Philipps-Universität, Baldingerstraße, 35043, Marburg, Deutschland

    M. Rothmund (Leiter der Klinik für Allgemeinchirurgie) (Leiter der Klinik für Allgemeinchirurgie)

  3. Deutschen Gesellschaft für Chirurgie, Steinhölzle 16, 89198, Westerstetten, Deutschland

    W. Hartel (Generalsekretär) (Generalsekretär)

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© 1998 Springer-Verlag Berlin Heidelberg

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Meyer, D., Otto, C., Gassel, HJ., Ulrichs, K., Thiede, A. (1998). Die Rolle der Apoptose in der Toleranzinduktion nach Leber- und Leber/Dünndarmtransplantation. In: Herfarth, C., Rothmund, M., Hartel, W. (eds) Chirurgisches Forum ’98. Langenbecks Archiv für Chirurgie, vol I/98. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72182-3_76

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  • DOI: https://doi.org/10.1007/978-3-642-72182-3_76

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-64277-0

  • Online ISBN: 978-3-642-72182-3

  • eBook Packages: Springer Book Archive

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