Transplantation of Embryonic Cortex into the Damaged Cortex of Adult Rats
Numerous experimental studies have been undertaken in animals to determine to what extent transplantation of cortical neurons could prove a useful treatment for cerebral cortical damage. Unfortunately, however, the behavioral findings that were derived from these experiments in adult animals gave conflicting results (for reviews, see Kolb and Fantie 1994; Roger and Ebrahimi-Gaillard 1994). Some studies indicated the existence of functional sparing or behavioral recovery following cortical damage and subsequent grafting of embryonic cortical tissue. Indeed, some improvement was reported in studies dealing with the gustatory (Bermudez-Rattoni et al. 1987; Yirmiya et al. 1988; Escobar et al. 1989; Lopez-Garcia et al. 1990; Fernandez-Ruiz et al. 1991) or occipital (Stein et al. 1985) cortex. The results were less consistent, however, in studies dealing with the prefrontal cortex (Labbe et al. 1983; Kesslak et al. 1986a; Stein and Mufson 1987; Stein et al. 1988; Fantie and Kolb 1990). Even though several studies reported some improvement in various cognitive tasks (Labbe et al. 1983; Kesslak et al. 1986a; Stein and Mufson 1987; Stein et al. 1988), the functional effect of the graft seemed to be highly dependent upon the experimental procedure (Dunnett et al. 1987; Kolb et al. 1988).
KeywordsCage Shrinkage Autocorrelation Stein Methacrylate
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