Application of Tetracycline Regulatable Systems for Gene Therapy
Many diseases candidates for gene therapy require that the therapeutic gene expression level is controlled in order to ensure biological efficacy and to prevent toxic effects. Various systems have been described which allow transcriptional regulation by artificial chimeric transactivators in mammalian cells. This paper describes the tetracycline regulatable systems and discuss their potential application for gene therapy.
KeywordsInducible Gene Expression Physiological Stimulus Foreign Gene Expression Gene Therapy Application Iron Response Element
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