Introduction

  • I. FitzGerald
  • I. Pastan
  • J. Robertus
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 234)

Abstract

While various treatment approaches for cancer include reversal of the transformed phenotype, stimulation of immune responses, inhibition of metastatic spread and deprivation of key nutrients, the goal of immunotoxin treatment is the direct killing of malignant cells. Because they are enzymatic proteins that act catalytically to kill cells, bacterial and plant toxins are often employed as the cell-killing component of immunotoxins. Here we provide background information into the structure-function relationships of toxins and discuss how they can be combined with cell-binding antibodies or other ligands to generate immunotoxins.

Keywords

Diphtheria Toxin Plant Toxin Single Chain Protein Recombinant Immunotoxins Diphtheria Toxin Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • I. FitzGerald
    • 1
  • I. Pastan
    • 1
  • J. Robertus
    • 2
  1. 1.Laboratory of Molecular Biology, Division of Basic SciencesNational Cancer Institute, NIHBethesdaUSA
  2. 2.Department of Chemistry and BiochemistryThe University of Texas at AustinAustinUSA

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