While various treatment approaches for cancer include reversal of the transformed phenotype, stimulation of immune responses, inhibition of metastatic spread and deprivation of key nutrients, the goal of immunotoxin treatment is the direct killing of malignant cells. Because they are enzymatic proteins that act catalytically to kill cells, bacterial and plant toxins are often employed as the cell-killing component of immunotoxins. Here we provide background information into the structure-function relationships of toxins and discuss how they can be combined with cell-binding antibodies or other ligands to generate immunotoxins.
KeywordsDiphtheria Toxin Plant Toxin Single Chain Protein Recombinant Immunotoxins Diphtheria Toxin Receptor
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