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Pharmakogenetische Determination der therapeutischen Wirkungen von Clozapin

  • W. Maier
  • M. Rietschel
Conference paper

Zusammenfassung

Trotz der sicher belegten Wirksamkeit der Neuroleptika zeigt keine der spezifischen Substanzen den erwünschten therapeutischen Erfolg in dem gewünschten Umfang: Es respondiert jeweils nur ein Teil der psychotisch Kranken, der therapeutische Effekt führt häufig nicht zur Remission, und oft treten unerwünschte Nebenwirkungen auf, die sogar zum Absetzen der Medikation zwingen können. In einer solchen Situation wären substanzspezifische Prädiktoren der therapeutischen Wirkung zum Zwecke der Optimierung der antipsychotischen Behandlung sehr hilfreich. Die bisherigen Untersuchungen zur Prädiktion des Therapieeffekts konnten aber keine sicheren Indikatoren extrahieren.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • W. Maier
  • M. Rietschel

There are no affiliations available

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