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Therapie von Risikopatienten mit Neuroleptika

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Therapie mit klassischen und neuen Neuroleptika

Zusammenfassung

Neuroleptika (NL) sind die Mittel der Wahl in der Behandlung schizophrener Psychosen; auch psychotische Syndrome bei affektiven Erkrankungen oder in der Folge anderer Krankheiten können mit NL in der Regel gut beeinflußt werden. Fast fünf Jahrzehnte pharmakologischer Erfahrung mit den klassischen NL und drei Jahrzehnte mit dem atypischen NL Clozapin haben Behandlungsregeln etabliert, die für den überwiegenden Teil der Therapien sichere und dem Patienten nutzbringende Wege aufzeigen. Die erheblichen Nebenwirkungsraten der klassischen NL, das Problem der Nonresponder und die unbefriedigende Beeinflußbarkeit der Negativsymptome chronifizierter Schizophrenien haben erhebliche Anstrengungen stimuliert, wirksamere, vor allem nebenwirkungsärmere Pharmaka zu entwickeln, die weitgehend das Rezeptorbindungsprofil des Clozapins zu imitieren oder zu modifizieren versuchen. Clozapin und die neueren Atypika haben unsere Vorstellungen über die pathophysiologischen Mechanismen der Schizophrenie von der reinen Dopaminhypothese weg zu einer Störung im Regelkreis glutamaterger, serotonerger, adrenerger und cholinerger zusammen mit dopaminergen Mechanismen erweitert.

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Authors
  1. R. Steinberg
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Editors and Affiliations

  1. Psychiatrische Klinik, Georg-August-Universität, von-Siebold-Straße 5, 37075, Göttingen, Deutschland

    Borwin Bandelow  & Eckart Rüther  & 

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© 1998 Springer-Verlag Berlin Heidelberg

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Steinberg, R. (1998). Therapie von Risikopatienten mit Neuroleptika. In: Bandelow, B., Rüther, E. (eds) Therapie mit klassischen und neuen Neuroleptika. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72152-6_15

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  • DOI: https://doi.org/10.1007/978-3-642-72152-6_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-64095-0

  • Online ISBN: 978-3-642-72152-6

  • eBook Packages: Springer Book Archive

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