Growth Inhibition of Human Fibroblasts in Vitro

  • Alvaro Macieira-Coelho
Part of the Progress in Molecular and Subcellular Biology book series (PMSB, volume 20)


Growth arrest of human fibroblasts maintained in vitro occurs when the density increases and the cells become confluent; this is the so-called contact inhibition of growth characteristic of all normal cells. Growth arrest also occurs at the end of the cell population’s proliferative life span, a state that has been erroneously called senescence but which is irrelevant for aging of the organism since the terminal cell is present in tissues in vivo in amounts unrelated to the age of the donor (Macieira-Coelho 1995). This terminal cell is supposed to be in a differentiated state (Martin et al. 1974), although its putative role in homeostasis has not been identified so far. An increased number of terminal fibroblasts was found in vivo under pathological conditions (Macieira-Coelho 1995).


Human Fibroblast Terminal Cell Rous Sarcoma Virus Human Diploid Fibroblast Population Doubling Level 
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© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • Alvaro Macieira-Coelho
    • 1
  1. 1.INSERMVersaillesFrance

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