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Intestinal Transplantation in the Murine Model

  • D. Quan
  • Z. Zhang
  • A. Jevnikar
  • R. Zhong
  • D. Grant

Abstract

Transplantation of the intestine (IT) may eventually become the definitive treatment for patients with the short gut syndrome [1]. In contrast to the clinical success of kidney, liver, and heart transplantation, IT remains an experimental procedure. Rejection, graft-versus-host disease, sepsis, and lymphoproliferative disorders continue to plague IT despite reports of increasing clinical experience [2]. It is clear that further research is required before IT can become a more widely available treatment option.

Keywords

Liver Abscess Technical Success Rate Warm Ischemia Time Intestinal Transplantation Small Bowel Transplantation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Grant DR, Wall WJ, Mimeault R, Zhong R, Ghent C, Garcia B, Stiller C, Duff JH (1990) Successful small bowel/liver transplantation. Lancet 335:181–184PubMedCrossRefGoogle Scholar
  2. 2.
    Grant D (1996) Current results of intestinal transplantation. Lancet 347:1801–1803PubMedCrossRefGoogle Scholar
  3. 3.
    Zhong R, Zhang Z, Quan D, Duff J, Stiller C, Grant D (1993) Development of a mouse intestinal transplantation model. Microsurgery 14: 141–145PubMedCrossRefGoogle Scholar
  4. 4.
    Grant DR, Zhong R, Hurlbut D, Garcia B, Chen H, Lamont D, Wang P, Stüler C, Duff JH (1991) A comparison of heterotopic and orthotopic intestinal transplantation in rats. Transplantation 51:948–954PubMedCrossRefGoogle Scholar
  5. 5.
    Zhong R, Grant D, Sutherland F, Wang P, Chen H, Lo S, Stiller C, Duff J (1991) Refined technique for intestinal transplantation in the rat. Microsurgery 12:268–274PubMedCrossRefGoogle Scholar
  6. 6.
    Rosemurgy AS, Schraut WH (1986) Small bowel allografts (sequence of histologic changes in acute and chronic rejection). Am J Surg 151:470–475PubMedCrossRefGoogle Scholar
  7. 7.
    Garcia B, Zhong R, Wijsman J, Wang P, Chen H, Sutherland F, Duff J, Grant D (1990) Pathological changes following intestinal transplantation in the rat. Transplant Proc 22:2469–2470PubMedGoogle Scholar
  8. 8.
    Grant DR, Hurlbut D, Zhong R, Wang P, Chen H, Garcia B, Behme R, Stiller C, Duff J (1991) Intestinal permeability and bacterial translocation following small bowel transplantation in the rat. Transplantation 51:221–224CrossRefGoogle Scholar
  9. 9.
    Quan D, Grant DR, Zhong R, Zhang Z, Garcia BM, Jevnikar AM (1994) Altered gene expression of cytokine, ICAM-1, and MHC class II molecules precedes mouse intestinal allograft rejection. Transplantation 58:808–816PubMedGoogle Scholar
  10. 10.
    Halloran PF, Wadgymar A, Autenried P (1986) The regulation of expression of major histocompatibility complex products. Transplantation 41:413–420PubMedCrossRefGoogle Scholar
  11. 11.
    Springer TA (1990) Adhesion receptors of the immune system. Nature 346:425–434PubMedCrossRefGoogle Scholar
  12. 12.
    Arai K-I, Lee F, Miyajima A, Miyatake S, Arai N, Yokota T (1990) Cytokines: coordinators of immune and inflammatory responses. Ann Rev Biochem 59:783–836PubMedCrossRefGoogle Scholar
  13. 13.
    Hurlbut D, Garcia B, Ohene-Fianko D, Duff J, Grant D (1992) Immunohistochemical assessment of mucosal biopsies following human intestinal transplantation. Transplant Proc 24:1195–1196PubMedGoogle Scholar
  14. 14.
    Quan D, Zhong R, Jevnikar AM, Zhang Z, Garcia BM, Grant DR (1996) Intestinal allograft rejection in lipopolysaccharide-hyporesponsive mice. Transplant Proc 28:2460–2461PubMedGoogle Scholar
  15. 15.
    Sultzer BM (1968) Genetic control of leukocyte responses to endotoxin. Nature 219:1253–1254PubMedCrossRefGoogle Scholar
  16. 16.
    Beutler B, Tkacenko V, Milsark I, Krochin N, Cerami A (1986) Effect of γ interferon on cachectin expression by mononuclear phagocytes. Reversal of the lps d (endotoxin resistance) phenotype. J Exp Med 164:1791–1796PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • D. Quan
  • Z. Zhang
  • A. Jevnikar
  • R. Zhong
  • D. Grant

There are no affiliations available

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