Abstract
During the past two decades, the results of clinical pancreas transplantation have improved considerably. Most pancreas transplantations are still performed as simultaneous pancreas/kidney transplantation (SPK) in patients with type I diabetes and end-stage nephropathy. Rejection of the pancreas graft and/or of the kidney in the case of SPK is still a major problem and requires potent immunosuppressive drugs. These drugs are associated with a widespread suppression of responsiveness of the immune system and numerous side effects, including susceptibility to infection and cancer. Many experimental models exist in large and small animals with the aim to overcome these problems and to induce long-term graft acceptance. In this chapter, we will elucidate the data from different immunosuppression protocols from the past few years to compare their potency in preventing rejection after pancreas transplantation in rats.
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References
Klempnauer J, Lück R, Brusch U, Steiniger B (1990) Comparison of graft morphology and endocrine function after vascularized whole pancreas transplantation in the rat by different surgical techniques. J Surg Res 49:69–80
Garvey JFW, McShane-Poole MD, Millard PR, Morris PJ (1980) The effect of cyclosporin A on experimental pancreas allografts in the rat. Transplant Proc 12:266–269
Klempnauer J, Wagner E, Wonigeit K, Pichlmayr R (1983) Pancreas and kidney allograft rejection responds differently to cyclosporin immunosuppression. Transplant Proc 15 [Suppl 1]:3001–3003
Timmermann W, Schang T, Thiede A (1985) The effect of temporary cyclosporin A treatment on the endocrine function of pancreaticoduodenal allografts in the rat. In: Thiede A, Deltz E, Engemann R, Hamelmann H (eds) Microsurgical models in rats for transplantation research. Springer, Berlin Heidelberg New York, pp 177–181
Königsrainer A, Dietze O, Habringer C, Krausler R, Klima G, Margreiter R (1991) Morphology of acute rejection and corresponding cytological findings in exocrine secretion after pancreas transplantation in the rat. Transplantation 52:770–777
Königsrainer A, Mark W, Hechenleitner P, Klima G, Dietze O, Margreiter R (1997) At what stage does pancreas allograft rejection become irreversible? Transplantation 63:631–635
Schang T, Zheng T, Sutherland D (1988) Monitoring urinary amylase and pH in pancreas transplantation with urinary drainage in rats. Transplantation 46:806–812
Vogt P, Hiller W, Steiniger B, Klempnauer J (1992) Differential response of kidney and pancreas rejection to cyclosporin immunosuppression. Transplantation 53:1269–1272
Chen H, Wu J, Luo H, Daloze P (1992) Synergistic effect of rapamycin and cyclosporin in pancreaticoduodenal transplantation in the rat. Transplant Proc 24:892–893
Ohtsuka S, Yokoyama I, Hayashi S, Haba T, Takagi H (1994) Experimental rat pancreas transplant: surgical technique and immunological considerations. Surg Today 24:247–253
Yamashita T, Maeda Y, Ishikawa T, Ohira M, Nakagawa H, Nagai Y, Park I, Yamamoto Y, Yoshikawa K, Cai R, Umeyama K (1991) Prolongation of pancreaticoduodenal allograft survival in rats by treatment with FK 506. Transplant Proc 23(6):3219–3220
Schulak JA, Krishnamurthi V, Masih R, Robinson A (1995) Effect of major histocompatibility disparity on mycophenolate mofetil immunosuppression in rat paneras transplantation. Transplant Proc 27(6):3010–3011
D’Silva M, De Roover A, Nishimura Y, Antoniou E, Candinas D, McMaster P (1996) Spectrum of susceptibility to rejection of heart and multivisceral small bowel allografts using leflunomide immunosuppression. Transplant Proc 28(2):948–949
Isobe M, Yagita H, Okomura K (1992) Science 255:1125
Spillenaar-Bilgen EJ, DeBruin RWF, Baumgartner D, Jekel J, Marquet RL (1990) Moderate effect of preoperative blood transfusions on pancreas allograft survival in rats and dogs. Transplantation 50:21–25
Leibel BS, Martin J, Chamberlain J, Zingg W (1994) Pretreatment with increasing doses of donor pancreas or blood induces tolerance to allogeneic pancreatic transplantation. Transplant Proc 26(6):3709–3714
Schulak J, Mulligan D, Robinson A (1997) Intrathymic spleen cell inoculation and ALS fails to induce tolerance to rat pancreas allografts. Transplant Proc 29:1070–1071
Nolan MS, Lindsey NJ, Savas CP, Herold A, Beck S, Slater DN, Fox M (1983) Pancreatic transplantation in the rat. Transplantation 36:26–33
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© 1998 Springer-Verlag Berlin Heidelberg
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Gasser, M., Otto, C., Timmermann, W., Thiede, A. (1998). Immunosuppression After Pancreas Transplantation. In: Timmermann, W., Gassel, HJ., Ulrichs, K., Zhong, R., Thiede, A. (eds) Organtransplantation in Rats and Mice. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72140-3_48
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DOI: https://doi.org/10.1007/978-3-642-72140-3_48
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