Immunosuppression After Pancreas Transplantation

  • M. Gasser
  • C. Otto
  • W. Timmermann
  • A. Thiede

Abstract

During the past two decades, the results of clinical pancreas transplantation have improved considerably. Most pancreas transplantations are still performed as simultaneous pancreas/kidney transplantation (SPK) in patients with type I diabetes and end-stage nephropathy. Rejection of the pancreas graft and/or of the kidney in the case of SPK is still a major problem and requires potent immunosuppressive drugs. These drugs are associated with a widespread suppression of responsiveness of the immune system and numerous side effects, including susceptibility to infection and cancer. Many experimental models exist in large and small animals with the aim to overcome these problems and to induce long-term graft acceptance. In this chapter, we will elucidate the data from different immunosuppression protocols from the past few years to compare their potency in preventing rejection after pancreas transplantation in rats.

Keywords

Cyclosporin Hyperglycemia Amylase Rapamycin Allo 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • M. Gasser
  • C. Otto
  • W. Timmermann
  • A. Thiede

There are no affiliations available

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