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Mucosal Immunology of the Small Bowel

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Organtransplantation in Rats and Mice

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Abstract

The small bowel is not merely a sac for the transportation and resorption of food, but also one of the most vulnerable surfaces of the body interacting with the external environment. In consequence, a specialized immune network has evolved to protect the organism from ingested pathogens; in addition, the small bowel possesses the property of preventing the organism from systemic reaction to ubiquitous dietary antigens. The specialized lymphoid tissue of the gut is comparable in structure and function to the lymphoid tissue of other mucosal sites, called mucosa-associated lymphatic tissue (MALT) [39], and is known as gut-associated lymphoid tissue (GALT). It consists of follicular lymphatic structures called Peyer’s patches found predominantly in the small bowel, ileum, appendix, and colon. In addition, there are a large number of nonorganized interfollicular lymphoid cells between the surface epithelium (intraepithelial lymphocytes, IEL) and in the lamina propria (lamina propria lymphocytes, LPL). The covering epithelium also plays an important role in the uptake of and response to ingested antigens. In the following article, the structure and function of each of these compartments of the GALT will be discussed.

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Authors
  1. A. M. Gassel
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  2. A. Greiner
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Editors and Affiliations

  1. Chirurgische Universitätsklinik und Poliklinik Würzburg, Josef-Schneider-Straße 2, 97080, Würzburg, Germany

    Wolfgang Timmermann , Heinz-Jochen Gassel , Karin Ulrichs  & Arnulf Thiede , ,  & 

  2. Department of Surgery, University of Western Ontario, 339 Windermere Road, N6A 5A5, London, Ontario, Canada

    Robert Zhong

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© 1998 Springer-Verlag Berlin Heidelberg

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Gassel, A.M., Greiner, A. (1998). Mucosal Immunology of the Small Bowel. In: Timmermann, W., Gassel, HJ., Ulrichs, K., Zhong, R., Thiede, A. (eds) Organtransplantation in Rats and Mice. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72140-3_42

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  • DOI: https://doi.org/10.1007/978-3-642-72140-3_42

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-72142-7

  • Online ISBN: 978-3-642-72140-3

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