Immunosuppression in Experimental Heart Transplantation

  • M. T. Menard
  • J. C. Madsen


Advances in immunosuppression have had a significant impact on the field of whole-organ transplantation. New chemical agents utilizing novel mechanisms have been developed, resulting in prolonged survival times in both the experimental and clinical arenas. Despite the improved efficacy of these new nonspecific immunosuppressive agents, host susceptibility to infection and malignancy and organ-specific toxicities are still serious constraints. Thus, more specific “biologic” immunosuppression has been developed in the form of monoclonal antibodies which target specific populations of alloreactive T cells. These reagents theoretically spare the overall defense capabilities of the host by targeting only those lymphocytes which interact with donor antigen. This chapter reviews the important chemical and biologic immunosuppressive agents that have been evaluated in rodent models of heart transplantation.


Transplant Proc Cardiac Allograft Cardiac Allograft Vasculopathy Heart Allograft Donor Antigen 
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© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • M. T. Menard
  • J. C. Madsen

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