Venovenous Allotransplantation in the Rat
In previous studies, Engemann et al.  and Körner  were able to demonstrate that vein grafts transplanted into the venous system have the capacity to sensitize allogeneic recipients. Vein grafting led to accelerated rejection of subsequent donor-type skin grafts and to the production of cytotoxic antibodies to donor-type tissue. However, all allogeneic vein grafts showed long-term patency, and histologically they appeared to be intact when investigated between 20 and 100 days postoperatively. In particular, no mononuclear cellular infiltrations could be found within this period. Allogeneic vein grafts in nonim-munosuppressed recipients were not distinguishable from syngeneic vein grafts 100 days postoperatively. These findings were unexpected, because both arterial allografts [5, 6] and venous allografts  used for arterial replacement in the rat underwent a marked cellular infiltration even if long-term patency was achieved. Therefore, the aim of our study was to compare syngeneic and allogeneic venovenous grafts by means of morphometric methods. Especially morphological alterations of the vein grafts during the early postoperative phase were to be investigated.
KeywordsHematoxylin Eosin Polymethylmethacrylate Allo
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