Abstract
A widely distributed understanding defines immunology as the science of self/nonself-discrimination. However, to discriminate an individual’s own tissues from genetically different ones and, more importantly, from structures which do not belong to its own species is by no means the speciality of the immune system. This capacity is vital for all invertebrates and vertebrates because of biotic threats to individuality, such as cellular or microbial parasitism. There is a wide variety of recognition systems, most of them poorly understood, such as lectins, adhesion molecular systems, and other systems of so-called innate immunity and specific immunity. In evolutionary terms, the latter developed relatively late, some 300–350 million years ago, among the deuterostomata; some people call it the ingenious immuno big bang of nature. Since then molecules are created which are composed of several variable regions, allowing a large variety of reaction specificities by genetic rearrangements of these regions. Rearrangement rather than prearrangement is the ingenious principle which became applied twofold, namely in T-lymphocyte cell surface receptors and in humoral antibodies, and which allows for a tremendous diversification of reaction specificities of these molecules.
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References
Akbar AN Salmon M (1997) Cellular environments and apoptosis: tissue microenvironments control activated T cell death. Immunol Today 18:72–76
Azuma H, Paul LC, Tilney NL (1996) Insights into acute and chronic rejection. Transplant Proc 28:2081–2084
Benichou G, Tarn RC, Soares LRB, Fedoseyeva EV (1997) Indirect T-cell derecognition: perspectives for peptide-based therapy in transplantation. Immunol Today 18:67–71
Bluestone JA (1996) Costimulation and its role in organ transplantation. Clin Transplant 10:104–109
Brazelton TR, Morris RE (1996) Molecular mechanisms of action of new xenobiotic immunosuppressive drugs: tacrolimus (FK506), sirolimus (rapamycin), mycophenolate mofetil and leflunomide. Curr Opin Immunol 8:710–720
Brenner M, Porcelli S (1997) Antigen presentation: a balanced diet. Science 277:332
Calhoun R, Mohanakumar T, Flye MW (1996) Tissue- and organ-specific immune responses: role in human disease and allograft immunity. Transplant Rev 10:34–45
Calne R (1997) Progress toward tolerance and xenografting. Transplant Proc 29:16–18
Chambers CA, Allison JP (1997) Co-stimulation in T cell responses. Curr Opin Immunol 9:396–404
Chatenoud L (1997) Biological immunosuppressants: the way to clinical transplantation tolerance. Transplant Proc 29:51–55
Däëron M (1997) ITIM-bearing negative coreceptors. Immunologist 5: 79–86
Dalloul AH, Chmouzis E, Ngo K, Fung-Leung WP-P (1996) Adoptively transferred CD4+ lymphocytes from CD8-/- mice are sufficient to mediate the rejection of MHC class II or class I disparate skin grafts. J Immunol 156:4114–4119
Davies JD, Cobbold SP, Waldmann H (1997) Strain variation in susceptibility to monoclonal antibody-induced transplantation tolerance. Transplantation 63:1570–1573
Doherty PC, Zinkernagel RM (1975) A biological role for the major histocompatibility antigens. Lancet 1: 406–409
Field EH, Gao Q, Chen N, Rouse TM (1997) Balancing the immune system for tolerance. Transplantation 64:1–7
Forbes RDC, Zheng SX-X, Gomersall M, Guttmann RD (1997) Irreversible chronic vascular rejection occurs only after development of advanced allograft vasculopathy. Transplantation 63:743–749
Giangrande J, Yamada K, Arn S, Lorf T, Sachs DH, LoGuern C (1997) Selective increase in CD4-positive graft-infiltrating mononuclear cells among the infiltrates in class I disparate kidney grafts undergoing rejection. Transplantation 63:722–728
Goldstein J, Mortowsky H, Tung J, Hon H, Brunswick M, Kozlowski S (1997) Naive allo-reactive CD8 T cells are activated by purified major histocompatibility complex class I and antigenic peptide. Eur J Immunol 27:871–878
Goodnow CC (1996) Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires. Proc Natl Acad Sci U S A 93:2264–2271
Granstein RD (1996) New strategy for allotransplantation. Lancet 348:838–839
Grewal IS, Flavell RA (1996) A central role of CD40 ligand in the regulation of CD4+ T cell responses. Immunol Today 17:410–414
Halloran PF (1996) Molecular mechanisms of new immunosuppressants. Clin Transplant 10:118–123
Halloran PF, Homik J, Goes N, Lui SL, Urmson J, Ramassar V, Cockfield SM (1997) The “injury response”: a concept linking nonspecific injury, acute rejection, and long-term transplant outcomes. Transplant Proc 29:79–81
Häyry P (1995) Aspects of allograft rejection, I: molecular pathology of acute and chronic rejection. Transplant Rev 9:113–120
Häyry P, Myllärniemi M, Ramirez LC, Aavik E, Loubtchenkov M, Koskinen P, Lemström K, Räisänen-Sokolowski A (1997) Immunobiology and pathology of chronic rejection. Transplant Proc 29:77–78
Jankowsi RA, Ildstad ST (1996) Current progress in chimerism and donor-specific tolerance. Transplant Proc 28:2071–2074
Kasahara M, Flajnik MF, Ishibashi T, Natori T (1995) Evolution of the major histocompatibility complex: a current overview. Transplant Immunol 3:1–20
Kemeny DM, Noble A, Holmes BJ, Diaz-Sanchez D (1994) Immune regulation: a new role for the CD8+ T cell. Immunol Today 15:107–110
Kroemer G (1997) The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nature Med 3:614–620
Kruisbeek AM, Amsen D (1996) Mechanisms underlying T-cell tolerance. Curr Opin Immunol 8:233–244
Lafferty KJ (1995) Role of second signals in the induction of T cells and graft rejection. Immunologist 3:256–258
Lau HT, Stoeckert CJ (1997) FasL — too much of a good thing? Nature Med 3:727–728
Lu L, Qian S, Hershberger PA, Rudert WA, Lynch DM, Thomson AW (1997) Fas ligand (CD95L) and B7 expression on dendritic cells provide counter-regulatory signals for T cell survival and proliferation. J Immunol 158:5676–5684
Matechak EO, Killeen N, Hedrick SM, Fowlkes BJ (1996) MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent. Immunity 4:337–347
Metcalf D (1997) Another way to generate T cells? Nature Med 3:18–19
Müller-Ruchholtz W (1992) Specific down-regulation of allograft reactivity at the cellular level: graft cells and responder T cells. Immunol Lett 32:1–6
Müller-Ruchholtz W (1998) Glances at the history of transplantation. Transplant Proc 30: (in press)
Murphy B, Sayegh M (1996) Why do we reject a graft? Mechanisms of recognition of transplantation antigens. Transplant Rev 10:150–159
Nadeau KC, Azuma H, Tilney NL (1996) Cytokines in the pathophysiology of acute and chronic allograft rejection. Transplant Rev 10:99–107
Naji A (1996) Induction of tolerance by intrathymic inoculation of alloantigen. Curr Opin Immunol 8:704–709
O’Shea JJ (1997) Key molecules involved in receptor-mediated lymphocyte activation. Curr Protocols Immunol [Suppl 22]: A.1J, 1–14
Orosz CG, Bergese SD, Wakely E, Xia D, Gordillo GM, VanBuskirk AM (1997) Acute versus chronic graft rejection: related manifestations of allosensitization in graft recipients. Transplant Rev 11:38–50
Paul LC (1995) Aspects of allograft rejection, III. Transplant Rev 9:127–137
Pennisi E (1996) Teetering on the brink of danger. Science 271:1665–1667
Perez VL, VanParijs L, Biuckians A, Zheng XX, Strom TB, Abbas AK (1997) Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity 6:411–417
Piccotti JR, Chan SY, VanBuskirk AM, Eichwald EJ, Bishop DK (1997) Are Th2 helper T lymphocytes beneficial, deleterious, or irrelevant in promoting allograft survial? Transplantation 63:619–624
Pion S, Fontaine P, Desaulniers M, Jutras J, Filep JG, Perreault C (1997) On the mechanisms of immunodominance in cytotoxic T lymphocyte responses to minor histocompatibility antigens. Eur J Immunol 27:421–430
Pirenne J, Benedetti E, Dunn DL (1996) Graft versus host response: clinical and biological relevance after transplantation of solid organs. Transplant Rev 10:46–68
Quill H (1996) Anergy as a mechanism of peripheral T cell tolerance. J Immunol 156:1325–1327
Rodriguez-Iturbe B (1996) Cellular adhesion molecules in transplantation. Tranplant Proc 28:3285–3289
Ross R (1996) Genetically modified mice as models of transplant atherosclerosis. Nature Med 2:527–528
Rothenberg EV (1996) How T cells count. Science 273:78–79
Schwartz RH (1996) Models of T cell anergy: is there a common molecular mechanism? J Exp Med 184:1–8
Scully R, Cobbold SP, Mellor AL, Wissing M, Arnold B, Waldmann H (1997) A role for Th2 cytokines in the suppression of CD8+ T cell-mediated graft rejection. Eur J Immunol 27:1663–1670
Soares LRB, Rivas A, Tsavaler L, Engleman EG (1997) Ligation of the V7 molecule on T cells blocks anergy induction through a CD28-independent mechanism. J Immunol 159:1115–1124
Steiger J, Nickerson PW, Steurer W, Moscovitch-Lopatin M, Strom TB (1995) IL-2 knockout recipient mice reject islet cell allografts. J Immunol 155:489–498
Steinman L (1996) A few autoreactive cells in an autoimmune infiltrate control a vast population of nonspecific cells: a tale of smart bombs and the infantry. Proc Natl Acad Sci U S A 93:2253–2256
Streilein JW (1996) Peripheral tolerance induction: lessons from immune privileged sites and tissues. Transplant Proc 28:2066–2070
Sundstrom JB, Ansari AA (1995) Comparative study of the role of professional versus semiprofessional or nonprofessional antigen presenting cells in the rejection of vascularized organ allografts. Transplant Immunol 3:273–289
Sykes M (1996) Chimerism and central tolerance. Curr Opin Immunol 8:694–703
Sykes M, Szot GL, Swenson KA, Pearson DA (1997) Induction of high levels of allogeneic hematopoietic reconstitution and donor-specific tolerance without myelosuppressive conditioning. Nature Med 3:783–787
Ward ES, Qadri A (1997) Biophysical and structural studies of TCRs and ligands: implications for T cell signaling. Curr Opin Immunol 9:97–106
Watts C (1997) Inside the gearbox of the dendritic cell. Nature 388:724–725
Wen T, Kono K, Shahinian A, Kiessling R, Mak TW, Klein G (1997) CD28 is not required for rejection of unmanipulated syngeneic and autologous tumors. Eur J Immunol 27:1988–1993
Yang E, Korsmeyer SJ (1996) Molecular thanatopsis: a discourse on the BCL2 family and cell death. Blood 88:386–401
Zavazava N, Krönke M (1996) Soluble HLA class I molecules induce apoptosis in alloreactive cytotoxic T lymphocytes. Nature Med 2:1005–1010
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Müller-Ruchholtz, W. (1998). Concepts and Mechanisms of Immune Activation, Graft Rejection, Immunosuppression, and Tolerance. In: Timmermann, W., Gassel, HJ., Ulrichs, K., Zhong, R., Thiede, A. (eds) Organtransplantation in Rats and Mice. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72140-3_27
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DOI: https://doi.org/10.1007/978-3-642-72140-3_27
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