Abstract
Pancreatic transplantation has now become an established and relatively safe procedure for the cure of diabetes. While 15 years ago estimates of 1-year graft survival were only 21% [12], the many alterations in immunosuppression and surgical procedure that have been made have improved this figure to over 80% [4]. This improvement has been the result mainly of experimental evaluations in microsurgical models. Technical considerations such as drainage of the exocrine secretion have been thoroughly investigated in rat models [7], and inbred rat combinations have served as models for immunological questions.
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References
Dubernard JM, Traeger J, Bosi E et al (1984) Transplantation for the treatment of insulin-dependent diabetes: clinical experience with polymere-obstructed pancreatic grafts using Neoprene. World J Surg 8:262–266
Klempnauer J, Settje A (1989) Vascularized pancreas transplantation in the rat - details of the microsurgical techniques, results and complications. Transplant Int 2:84–91
Kobayashi E, Naoshi K, Nobuyuki T et al (1994) Successful methods of pancreas transplantation in the rat using a cuff technique. Aust NZ J Surg 64:491–493
Kuo PC, Johnson LB, Schweitzer EJ et al (1997) Simultaneous pancreas/kidney transplantation — a comparison of enteric and bladder drainage of exocrine pancreatic secretions. Transplantation 63 (2):238–243
Land W, Illner WD, Abendroth D et al (1984) Experience with 13 segmental pancreas transplants in cyclosporin treated diabetic patients using Ethibloc for duct obliteration (surgical aspects). Transplant Proc 16:729–732
Nolan MS, Lindsey NJ, Savas CP et al (1982) Pancreatic transplantation in the rat: a simplified method using aortic interposition and cuff techniques. Transplantation 33:327–329
Nolan MS, Lindsey NJ, Savas CP et al (1983) Pancreatic transplantation in the rat. Transplantation 36:26–33
Olausson M, Mjornstedt L, Lindholm L et al (1984) Non-suture organ grafting to the neck vessels in the rat. Acta Chir Scand 150:463–467
Schang T, Timmermann W, Thiede A (1985) Various techniques of experimental pancreas transplantation in the rat. In: Thiede A, Deltz E, Engemann R, Hamelmann H (eds) Microsurgical models in rats for transplantation research. Springer, Berlin Heidelberg New York, pp 57–63
Schang T, Zheng TL, Sutherland DER (1988) Monitoring urinary amylase and pH in pancreas transplantation with urinary drainage in rats. Transplantation 46:806–812
Sutherland DER, Chinn PL, Elick BA et al (1984) Maximization of islet mass in pancreas grafts by near total or total whole organ excision without the duodenum from cadaver donors. Transplant Proc 16:115–119
Sutherland DER, Chow SY, Moudry-Munns KC et al (1989) International transplant registry report — 1988. Clin Transplant 3:129–149
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© 1998 Springer-Verlag Berlin Heidelberg
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Hamelmann, W.H., Klöck, G., Timmermann, W. (1998). Pancreas Transplantation in Rats. In: Timmermann, W., Gassel, HJ., Ulrichs, K., Zhong, R., Thiede, A. (eds) Organtransplantation in Rats and Mice. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72140-3_13
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DOI: https://doi.org/10.1007/978-3-642-72140-3_13
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