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Etiology and Prevention of Emesis Induced by Radiotherapy

  • Petra C. Feyer
  • Alan L. Stewart
  • Otto J. Titlbach
Conference paper

Abstract

The introduction of new antiemetics has resulted in renewed interest in the etiology and control of radiation-induced emesis. Studies both with fractionated treatment and with high-dose single exposures have clearly demonstrated the value of the 5-HT3 receptor antagonist antiemetics. This paper reviews the selection of optimal antiemetics.

Keywords

Total Body Irradiation Antiemetic Therapy Antiemetic Prophylaxis Emetic Episode Chemoreceptor Trigger Zone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Anno GH, Baum SI, Withers HR, Young RW (1989) Symptomatology of acute radiation effects in humans after exposure to doses of 0.5–30 Gy. Health Phys 56: 821–838PubMedCrossRefGoogle Scholar
  2. 2.
    Barret A (1982) Total body irradiation (TBI) before bone marrow transplantation in leukaemia: a cooperative study from the European Group for Bone Marrow Transplantation. Br J Radiol 55: 562–570CrossRefGoogle Scholar
  3. 3.
    Belkacémi Y, Ozsahin M, Pène F, Rio B, Sutton L, Laporte JP, Touboul E, Gorin NC, Laugier A (1996) Total body irradiation prior to bone marrow transplantation: efficacy and safety of granisetron in the prophylaxis and control of radiation-induced emesis. Int J Radiat Oncol Biol Phys 36: 77–82PubMedGoogle Scholar
  4. 4.
    Blower PR (1990) The role of specific 5-HT3-receptor antagonsim in the control of cytostatic drug-induced emesis. Eur J Cancer 26 [Suppl 1]: 8–11Google Scholar
  5. 5.
    Bremer K (1994) Individuelle risikoadaptierte antiemetische Stufentherapie. Dtsch Med Wochenschr 119: 598–604PubMedCrossRefGoogle Scholar
  6. 6.
    Buell MG, Harding RK (1989) Proinflammatory effects of local irradiation on the rat gastrointestinal tract. Dig Dis Sci 34: 390–399PubMedCrossRefGoogle Scholar
  7. 7.
    Croockewit S (1990) The efficacy of ondansetron in emesis induced by total body irradiation (abstract). ESMO, Satellite Symposium on Zofran, pp 15–17Google Scholar
  8. 8.
    Court-Brown WM (1953) Symptomatic disturbance after single therapeutic dose of x-rays. Br J Med I: 802–805Google Scholar
  9. 9.
    Coates A, Abraham SK, Kaye SB (1983) On the receiving end: patient perception of the side effects of cancer chemotherapy. Eur J Cancer Clin Oncol 19: 203PubMedCrossRefGoogle Scholar
  10. 10.
    Danjoux E, Rider WD, Fritzpatrick PJ (1979) The acute radiation syndrome. Clin Radiol 30: 581–584PubMedCrossRefGoogle Scholar
  11. 11.
    Davis CJ, Harding RK, Leslie RA, Andrews PLR (1986) The organization of vomiting as a protective reflex. In: Davis CJ, Lake-Bakaar GV, Grahame-Smith DG (eds) Nausea and vomiting: mechanisms and treatment. Springer, Berlin Heidelberg New York, pp 65–75CrossRefGoogle Scholar
  12. 12.
    Feyer PC (1994) Incidence of emesis and nausea in fractionated radiotherapy patients. In: Advances in optimising the control of emesis. Satellite Symposium to ESMO, Lisbon, November 1994Google Scholar
  13. 13.
    Feyer P (1994) Investigations comparing acute reactions and late effects of different conditioning regimens prior to bone marrow transplantation. Thesis. University of LeipzigGoogle Scholar
  14. 14.
    Feyer P (1995) Ondansetron in radiotherapy-induced emesis. J Pharmacol Ther 4: 112–113Google Scholar
  15. 15.
    Fowler J, Lindstrom M (1992) Loss of local control with prolongation in radiotherapy. Int J Radiat Oncol Biol Phys 23: 457–467PubMedCrossRefGoogle Scholar
  16. 16.
    Franzen L, Nyman I, Hagberg H, Jakobsson M, Sorbe B, Nyth AL, Lomberg H, Henriksson R (1996) A randomised placebo controlled study with ondansetron in patients undergoing fractionated radiotherapy. Am Oncol 7: 587–592Google Scholar
  17. 17.
    Gagnon GJ, Kuettel M (1994) Diurnal variation in acute GI-toxicity from prostate cancer radiotherapy. Proc Am Soc Ther Radiol Oncol 1018: 253Google Scholar
  18. 18.
    Gibbs SJ, Casson AM (1996) A pilot study to evaluate the cost effectiveness of ondansetron and granisetron in fractionated total body irradiation. Clin Oncol 8: 182–184CrossRefGoogle Scholar
  19. 19.
    Harding RK (1995) 5-HT3 receptor antagonists and radiation-induced emesis: preclinical data. In: Reynolds DJM, Andrews PLR, Davis CJ (eds) Serotonin and the scientific basis of antiemetic therapy, chap 12. ( Oxford clinical communications) Oxford University Press, Oxford, pp 127–133Google Scholar
  20. 20.
    Harding RK, Leach KE, Prud’homme-Lalonde L, Ferrarotto CL (1991) Release of inflammatory mediators from irradiated gastrointestinal tissues. Gastroenterology 98: A285Google Scholar
  21. 21.
    Harding RK, Morris GP, Prud’homme-Lalonde L, Leach KE (1992) Acute effects of 5 Gy ionizing irradiation on mast cell populations in the ferret jejunum. Gastroenterology 102: A635Google Scholar
  22. 22.
    Harding RK, Young RW, Anno GH (1993) Radiotherapy-induced emesis. In: Andrews PLR, Sanger GJ (eds) Emesis in anticancer therapy mechanisms and treatment, chap 8. Chapman and Hall, London, pp 163–178Google Scholar
  23. 23.
    Henriksson R, Lomberg H, Isrealsson G, Zackrisson B, Franzen L (1992) The effect of ondansetron on radiation-induced emesis and diarrhoea. Acta Oncol 31: 767–769PubMedCrossRefGoogle Scholar
  24. 24.
    Hewitt M, Cornish J, Pamphilon D, Oakhill A (1991) Effective emetic control during conditioning of children for bone marrow transplantation using ondansetron, a 5-HT3 antagonist. Bone Marrow Transplant 7: 431–433PubMedGoogle Scholar
  25. 25.
    Hunter AE, Prentice HG, Pothecary K (1991) Granisetron, a selective 5HT3-receptor antagonist for the prevention of radiation-induced emesis during total body irradiation. Bone Marrow Transplant 7: 439–441PubMedGoogle Scholar
  26. 26.
    Jürgens H, McQuade B (1992) Ondansetron as prophylaxis for chemotherapy and radiotherapy induced emesis in children. Oncology 49: 279–285PubMedCrossRefGoogle Scholar
  27. 27.
    Kaasa S, Kvaly S, Lauvvang G (1993) The role of ondansetron in patients receiving total body irrradiation (abstract). Seventh ECCO: Progress in the Management of Emesis, Jerusalem, Israel, 14–18 November 1993Google Scholar
  28. 28.
    Krook JE, Moertel CG, Gunderson LL (1991) Effective surgical adjuvant therapy for high risk rectal carcinoma. N Engl J Med 324: 709PubMedCrossRefGoogle Scholar
  29. 29.
    Lucraft HH, Palmer MK (1982) Randomized clinical trial of levanantradol and chlorpromazine in prevention of radiotherapy-induced vomiting. Clin Radiol 33: 621–622PubMedCrossRefGoogle Scholar
  30. 30.
    Mirabell R, Coucke P, Behrouz F, Blazek N, Melliger M, Philipps S, Wickenhauser R, Gebhard S, Schwabb T, Rosset A (1995) Nausea and vomiting in fractionated radiotherapy: a prospective on-demand trial of tropisetron rescue for non-responders to metoclopramide. Eur J Cancer [Al 31: 1461–1464CrossRefGoogle Scholar
  31. 31.
    Prentice GH, Cunningham S, Gandhi L, Cunningham J, Collis C, Hamon MD (1995) Granisetron in the prevention of irradiation-induced emesis. Bone Marrow Transplant 15: 445–448PubMedGoogle Scholar
  32. 32.
    Priestman TJ (1989) Clinical studies with ondansetron in the control of radiation-induced emesis. Eur J Cancer Clin Oncol 251: 29–33Google Scholar
  33. 33.
    Priestman TJ, Priestman SG (1984) An initial evaluation of nabilone in the control of radiotherapy induced nausea and vomiting. Clin Radiol 35: 265–266PubMedCrossRefGoogle Scholar
  34. 34.
    Priestman TJ, Roberts JT, Upadhyaya BK (1992) Randomised double-blind trial of ondansetron and prochlorperazine in the prevention of fractionated radiotherapy induced emesis. Proc Am Soc Clin Oncol 9: 1370Google Scholar
  35. 35.
    Priestman TJ, Roberts JT, Upadhyaya BK (1993) A prospective randomized double-blind trial comparing ondansetron versus prochlorperazine for the prevention of nausea and vomiting in patients undergoing fractionated radiotherapy. Clin Oncol 5: 358–363CrossRefGoogle Scholar
  36. 36.
    Reyntjens R (1979) Domperidone as an anti-emetic: summary of research reports. Postgrad Med J 55: 50–54CrossRefGoogle Scholar
  37. 37.
    Roberts JT, Priestmann TJ (1993) A review of ondansetron in the management of radiotherapy induced emesis. Oncology 50: 173–179PubMedCrossRefGoogle Scholar
  38. 38.
    Robertson A, Robertson C, Symonds R (1993) Effect of varying schedules on carcinoma of the larynx. Eur J Cancer 29: 501–510CrossRefGoogle Scholar
  39. 39.
    Scarantino CW, Ornitz RD, Hoffmann LG, Anderson RF (1992) Radiation-induced emesis: effects of ondansetron. Semin Oncol 6 [Suppl 15]: 38–43Google Scholar
  40. 40.
    Scarantino CW, Ornitz RD, Hoffman LG, Anderson RF (1993) On the mechanism of radiation-induced emesis. The role of serotonin. Int J Radiat Oncol Biol Phys 27 [Suppl 1]: 159Google Scholar
  41. 41.
    Schwella N, König V, Schwerdtfeger R, Schmidt-Wolf I, Schmid H, Riess H, Siegert W (1994) Ondansetron for efficient emesis control during total body irradiation. Bone Marrow Transplant 13: 169–171PubMedGoogle Scholar
  42. 42.
    Sorbe B, Berglind AM, Bruijn K de (1992) Tropisetron, a new 5-HT3-receptor antagonist, in the prevention of radiation-induced emesis. Radiother Oncol 2: 131–132CrossRefGoogle Scholar
  43. 43.
    Spitzer TR (1995) Clinical evidence for 5-HT3 receptor antagonist efficacy in radiation-induced emesis. In: Reynolds DIM, Andrews PLR, Davis CJ (eds) Serotonin and the scientific basis of antiemetic therapy. ( Oxford clinical communications) Oxford University Press, Oxford, pp 134–141Google Scholar
  44. 44.
    Spitzer TR, Deeg HJ, Torrisi J (1990) Total body irradiation-induced emesis is universal after small dose fractions (120 cGy) and is not cumulative dose related. Proc Am Soc Clin Oncol 9: 14Google Scholar
  45. 45.
    Spitzer TR, Bryson JC, Cirenza E (1994) Randomized double-blind, placebo-controlled evaluation of oral ondansetron in the prevention of nausea and vomiting associated with fractionated total body irradiation. J Clin Oncol 12: 2432–2435PubMedGoogle Scholar
  46. 46.
    Sykes A, Kiltie A Stewart A (1997) Ondansetron versus a chlorpromazine and dexamethasone combination for the prevention of nausea and vomiting; a prospective, randomised study to assess the efficacy, costeffectiveness and quality of life in patients following single fraction radiotherapy. Support Care Cancer 5: 500–503PubMedCrossRefGoogle Scholar
  47. 47.
    Tiley C, Powles R, Caatalano J, Treleaven J, Eshelby J, Hewetson M, Tait D, Cunningham D (1992) Results of a double blind placebo controlled study of ondansetron as an antiemetic during total body irradiation in patients undergoing bone marrow transplantation. Leuk Lymphoma 7: 317–321PubMedCrossRefGoogle Scholar
  48. 48.
    Westbrook C, Glasholm J, Barrett A (1987) Vomiting associated with whole body irradiation. Clin Radiol 38: 263–266PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • Petra C. Feyer
  • Alan L. Stewart
  • Otto J. Titlbach

There are no affiliations available

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