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Optimal Selection of Antiemetics in Children Receiving Cancer Chemotherapy

  • Conference paper
Perugia Consensus Conference on Antiemetic Therapy

Abstract

Only a few studies have been carried out specifically on the prevention of nausea and vomiting in children receiving chemotherapy. In these patients, older antiemetic drugs such as metoclopramide and phenothiazines had moderate efficacy and induced significant side effects, especially marked sedation and extrapyramidal reactions.

In comparative trials, the 5-HT3 receptor antagonists have shown better efficacy and tolerability than chlorpromazine or metoclopramide combined with dexamethasone.

The combination of a 5-HT3 receptor antagonist plus dexamethasone is superior to a 5-HT3 receptor antagonist alone and should be the standard antiemetic prophylaxis in all pediatric patients receiving highly or moderately emetogenic chemotherapy.

The optimal dose and scheduling of these antiemetic drugs need to be studied, as well as the antiemetic efficacy, in the prevention of chemotherapy-induced delayed and anticipatory emesis in children.

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Authors
  1. Fausto Roila
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  2. Matti S. Aapro
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  3. Alan Stewart
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Editor information

Editors and Affiliations

  1. Ochsner Cancer Institute, 1514 Jefferson Highway, 70121-2483, New Orleans, LA, USA

    Richard J. Gralla

  2. Oncologia Medica, Policlinico Monteluce, Via Brunamonti, 06122, Perugia, Italy

    Maurizio Tonato  & Fausto Roila  & 

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© 1998 Springer-Verlag Berlin Heidelberg

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Roila, F., Aapro, M.S., Stewart, A. (1998). Optimal Selection of Antiemetics in Children Receiving Cancer Chemotherapy. In: Gralla, R.J., Tonato, M., Roila, F. (eds) Perugia Consensus Conference on Antiemetic Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72137-3_2

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  • DOI: https://doi.org/10.1007/978-3-642-72137-3_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-72139-7

  • Online ISBN: 978-3-642-72137-3

  • eBook Packages: Springer Book Archive

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