Abstract
An inference that can be drawn from Mendel’s first law is that contrasting alleles emerge from the heterozygotes without having influenced each other. Thus the pattern of expression of a gene with intact regulatory and coding regions is generally transmitted unchanged to the progeny upon segregation. However, exceptions to this rule have been observed in a number of organisms and include ‘epigenetic’ modifications of gene expression that are heritable and do not involve changes to the nucleotide sequence.
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References
Assaad F.F., Tucker K.L., Signer E.R. (1993) Epigenetic repeat-induced gene silencing (RIGS) in Arabidopsis. Plant Mol. Biol. 22: 1067–1085.
Bestor, T. (1990) DNA methylation: evolution of a bacterial immune function into a regulator of gene expression and genome structure in higher eukariotes. Philos. Trans. R. Soc. London Ser. B 326, 179–187.
Boyes, J., Bird, A. (1991) DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein. Cell, 64: 1123–1134.
Brink, R.A. (1958) Paramutation at the R locus in maize. Cold Spring Harbour Symp. Quant. Biol. 23: 379–391.
Brink, R.A. (1973) Paramutation. Annu. Rev. Genet. 7: 129–152.
Brutnell T P., Dellaporta S.L. (1994) Somatic inactivation and reactivation of Ac associated with changes in cytosine methylation and transposase expression. Genetics 138: 213–225
Chandler, V.L., Radicella, J.P., Robbins, T.P., Chen, J., Turks, D. (1989) Two regulatory genes of the maize anthocyanin pathway are homologous, isolation of b using r genomic sequences. Plant Cell 1: 1175–1183.
Chandler, V.L., Walbot, V. (1986) DNA modification of a maize transposable element correlates with loss of activity. Proc. Natl. Acad. Sci. USA, 83: 1767–71
Chomet, P.S., Wessler, S.T Dellaporta, S. (1987) Inactivation of the maize transposable element activator (Ac) is associated with DNA modification. EMBO J. 6: 295–302.
Cocciolone, M.S., Cone, K.C. (1993) Pl-Bh, an anthocyanin regulatory gene of maize that leads to variegated pigmentation. Genetics 153: 575–588.
Coe, E.H. (1966) The properties, origins and mechanism of conversion-type inheritance at the B locus in maize. Genetics 53: 1035–1063.
Cone, K.C., Burr F.A., Burr B. (1986) Molecular analysis of the maize anthocyanin regulatory locus CI. Proc. Natl. Acad. Sci. USA, 83: 9631–9635.
Cone, K. C., Cocciolone, S.M., Burr A.F., Burr B. (1993) Maize anthocyanin regulatory gene pi is a duplicate of cl that function in the plant. Plant Cell, 5: 1795– 1805.
Consonni, G., Geuna, F., Gavazzi, G., Tonelli, C. (1993) Molecular homology among members of the R gene family in maize. Plant Journal 3. 335–346.
Dooner H.K., Robbins T.P., Jorgensen R.A. (1991) Genetic and developmental control of anthocyanins biosynthesis. Ann. Rev. Genet 25: 173–199.
Dooner, H.K., Kermicle, J.L. (1971) Structure of the Rr tandem duplication in maize. Genetics 67: 427–436.
Eggleston, W.B., Alleman, M., Kermicle, J.L. (1995) Molecular organization and germinal instability of R-stippled in maize. Genetics, 141: 347–360.
Fedoroff, N, Schlappi, M., Raina, R. (1996) Epigenetic regulation of the maize Spm transposon. Bioessays 17. 291–294.
Flavell, R.B. (1994) Inactivation of gene expression in plants as a consequence of novel sequence duplication. Proc. Natl. Acad. Sci. USA, 91: 3490–3496.
Freedman, T., Pukkila, P.J. (1993) De novo methylation of repeated sequences in Coprinus cinereus. Genetics, 135: 357–366.
Fundele, I.H.R., Surani, A. M. (1994) Experimental embryological analysis of genetic imprinting in mouse development. Develop. Genet. 15: 515–522.
Grierson, D., Fray, R.G., Hamilton, A.J., Smith, C.J.S., Watson, C.F. (1991) Does co-suppression of sense genes in transgenic plants involve antisense RNA? Trends Biotech. 9. 122–123.
Hagemann, R. (1969) Somatic reversion (paramutation) at the Sulfurea locus of Lycopersicon esculentum. Ill Studies with trisomies. CanJ.Genet.CytoL 11: 346– 358.
Hollick, J.B., Patterson, G:I:, Coe, E.H.Jr., Cone, C.K., Chandler, V.L. (1995) Allelic interactions heritably alter the activity of a metastable maize pl allele. Genetics, 141: 709–719.
Jorgenssen, R. (1994) Developmental significance of epigenetic impositions on the plant genome: a paragenetic function for chromosomes. Develop. Genet., 15: 523– 532.
Kermicle, J.L. (1973) Organization of paramutational components of the R locus in maize. Basic mechanisms in plant morphogenesis. Brookhaven Symposia in Biology, 25: 262–278.
Kermicle, J.L., Eggleston, W.B., Alleman, M. (1995) Organization of paramutagenicity in R-stippled maize. Genetics, 141: 361–372.
Kricker, M.C., Drake,J.W., Radman, M. (1992) Duplication-targeted DNA methylation and mutagenesis in the evolution of eukaryotic chromosomes. Proc. Natl. Acad. Sci. USA 89, 1075–79.
Lloyd, A M., Walbot, V., Davis, R.W. (1992) Arabidopsis and Nicotiana anthocyanin production activated by maize regulators R and CI, Science 258: 1773–1775.
Ludwig. SR., Habera, L.F., Dellaporta, S.L., Wessler, S.R. (1989) Lc, a member of the maize R gene family responsible for tissue-specific anthocyanin production, encodes a protein similar to transcriptional activators and contains the myc- homology region. Proc. Natl. Acad. Sci. USA, 86: 7092–7096.
Martienssen, R. (1996) Paramutation and gene silencing in plants. Curr.Biol. 6: 810– 813.
Matzke, M.A., Matzke, A.J. M. (1993) Genomic imprinting in plants: parental effects and trans-inactivation phenomena. Annu. Rev. Plant Physiol. Plant. Mol. Biol. 44: 53–76.
Matzke M.A., Matzke A.J.M., Eggleston, B. (1996) Paramutation and transgene silencing: a common response to invasive DNA ? Trends Plant Sci. 1: 382–388.
McClintock, B. (1967) Regulation of pattern of gene expression by controlling elements in maize. Carnegie Inst. Yearb. 65: 568–78.
Meehan R.R., Lewis J.D., McKay S., Kleiner E.L., Bird A.P. (1989) Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs. Cell 58: 499–507.
Meyer, P., Saedler, H. (1996) Homology-dependent gene silencing in plants. Annu. Rev. Plant Physiol. Plant Mol. Biol. 47: 23–48.
Pandit, N.N., Russo, V.E.A. (1992) Reversible inactivation of a foreign gene, hph, during the sexual cycle of Neurospora crassa transformants. Mol. Gen. Genet. 234: 412–422.
Patterson, I. G., Thorpe, J.C., Chandler, L. V. (1993) Paramutation, an allelic interaction, is associated with a stable and heritable reduction of transcription of the maize b regulatory gene. Genetics 135: 881–894
Paz-Ares, J., Ghosal D., Wienand, U., Peterson, P.A., Saedler, H. (1987) The regulatory CI locus of Zea mays encodes a protein with homology to myb proto- oncogene products and with structural similarities to transcriptional activators. EMBO J. 6: 3553–3558.
Procissi, A.,S. Dolfini, A. Ronchi, C.Tonelli. (1997) Light-dependent spatial regulation and temporal expression of pigment regulatory genes in developing maize seeds The Plant Cell 9: (in press)
Rhounim, L., Rossignol, J.L., Faugeron, G. (1992) Epimutation of repeated genes in Ascobolus immersus. EMBO J. 11: 4451–4457.
Romano, N., Macino, G. (1992) Quelling: transient inactivation of gene expression in Neurospora crassa by trasformation with homologous sequences. Mol. Mic. 6: 3343–53.
Ronchi, A., Petroni, K., Tonelli, C. (1995) The reduced expression of endogenous duplications ( REED) in the maize R gene family is mediated by DNA methylation. EMBO J., 14: 5318–5328.
Selker, E.U. (1990) Premeiotic instability of repeated sequences in Neurospora crassa. Annu. Rev. Genet. 24: 579–613.
Tonelli, C. Consonni, G., Faccio Dolfini, S. Dellaporta, S.L., Viotti, A., Gavazzi, G. (1991) Genetic and molecular analysis of Sn, a light-inducible, tissue-specific regulatory gene in maize. Mol. Gen. Genet. 225: 401–410.
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Ronchi, A., Pilu, R., Tonelli, C. (1998). Silencing of Gene Expression in the Anthocyanin Regulatory Gene Families. In: Lo Schiavo, F., Last, R.L., Morelli, G., Raikhel, N.V. (eds) Cellular Integration of Signalling Pathways in Plant Development. NATO ASI Series, vol 104. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72117-5_9
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DOI: https://doi.org/10.1007/978-3-642-72117-5_9
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