mRNA Decay Machinery in Plants: Approaches and Potential Components
The abundance of a given mRNA is an important determinant of gene expression. This steady-state level is determined by a combination of the rates of synthesis and degradation of mRNA. Control at the level of message stability is of particular importance for genes whose expression is tightly regulated. Rapid degradation of transcripts in concert with transcriptional repression allows for the level of a transcript in the cytoplasm to be quickly diminished. This precise control of gene expression, afforded by rapid mRNA turnover, likely plays a significant role for plants, since as sessile organisms they must be able to quickly adapt to changes in the environment.
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- Chen C-YA, Shyu A-B (1995) AU-rich elements: characterization and importance in mRNA degradation. Trends Biochem. Sci. 20: 465–470Google Scholar
- Newman TC, de Bruijn F, Green PJ, Keegstra K, Kende H, Mcintosh L, Ohlrogge J, Raikhel NV, Somerville SC, Tomashow M, Retzel E, Somerville CR (1994) Genes Galore: A summary of methods for accessing results from partial sequencing of anonymous Arabidopsis cDNA clones. Plant Physiology 106: 1241–1255Google Scholar
- Sullivan ML, Green PJ (1993) Post-transcriptional regulation of nuclear-encoded genes in higher plants: the roles of mRNA stability and translation. Plant Mol. Biol. 23: 1091–1104Google Scholar
- Tharun S and Parker R (1997) Mechanisms of mRNA Turnover in Eukaryotic Cells. In JB Harford, D Morris, eds, mRNA Metabolism & Post-Transcriptional Gene Regulation, Vol 17. Wiley-Liss Inc, pp 181–200Google Scholar
- van Hoof A and Green, PJ Mechanisms of mRNA Turnover in Eukaryotic Cells. In JB Harford, D Morris, mRNA Metabolism & Post-Transcriptional Gene Regualtion, Vol 17. Wiley-Liss Inc, pp 181-200Google Scholar