Abstract
The boron microscopic distribution in brain tissue sections is an extremely important issue for the success of boron neutron capture therapy for cancer. We present the first results of a new approach to assess this distribution and its homogeneity: photoelectron spectromicroscopy with synchrotron radiation enabled us to detect boron in rat brain tissue specimens with a lateral resolution of 0.2 μm and a detection sensitivity of a few ppm. These experiments were performed by the newly commissioned MEPHISTO spectromicroscope (from the French acronym “Microscope ä Emission de Photoé lectrons par Illumination Synchrotronique de Type Onduleur”, or “Photoelectron Emission Microscope by Synchrotron Undulator Illumination”). The specimens were brain tissue sections from two rats injected with BPA (boronophenylalanine) or BSH (dodecahydro-dodecaborate). We found boron only in cancer-related structures, and with a higher concentration in the BPA-treated specimens than in the BSH-case. These results are in good agreement with the quantitative results obtained by inductively coupled plasma atomic emission spectroscopy.
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de Stasio, G. (1998). Microchemical Analysis of Boron in Rat Brain Tumor: A Spectromicroscopy Study with MEPHISTO. In: Thieme, J., Schmahl, G., Rudolph, D., Umbach, E. (eds) X-Ray Microscopy and Spectromicroscopy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72106-9_29
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DOI: https://doi.org/10.1007/978-3-642-72106-9_29
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