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Reoviruses II pp 163-177 | Cite as

Mucosal Immunity to Reovirus Infection

  • A. S. Major
  • D. H. Rubin
  • C. F. Cuff
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 233/2)

Abstract

The immune systems of the gastrointestinal, respiratory, and urogenital tracts are the first lines of defense against viral pathogens that infect via the host’s mucosal surfaces. Antigen-specific anti-viral mucosal immunity includes both humoral and cellular components which consist of virus-specific IgA (and to a lesser extent IgM and IgG), T helper (Th), and cytotoxic T lymphocytes (CTL). An understanding of viral pathogenesis and immunity at mucosal surfaces is important when considering approaches to developing protective and efficacious vaccines and delivery systems for gene therapy. However, the tedious nature of isolating immune cells from mucosal tissues and the lack of animal models for many viral diseases presents unique challenges to viral immunologists.

Keywords

Neonatal Mouse Mucosal Immunity Mucosal Immune Response Reovirus Infection Reovirus Type 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • A. S. Major
    • 1
  • D. H. Rubin
    • 2
    • 3
  • C. F. Cuff
    • 1
  1. 1.Department of Microbiology and Immunology, Robert C. Byrd Health Sciences CenterWest Virginia University School of MedicineMorgantownUSA
  2. 2.Research MedicineVeterans Affairs Medical CenterNashvilleUSA
  3. 3.Departments of Medicine, Microbiology and ImmunologyVanderbilt UniversityNashvilleUSA

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