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Pathogenesis of Reovirus Gastrointestinal and Hepatobiliary Disease

  • Chapter
Reoviruses II

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 233/2))

Abstract

During the initial surveys in search of viral infectious agents carried out in the late 1940s to the 1960s reovirus was discovered to be a common infectious agent that was recovered from the feces of virtually all mammals (Rosen and Abinanti 1960; Hrdy et al. 1979). In humans, exposure to the mammalian reovirus occurs in childhood, with a high proportion of the population having serological evidence of infection by young adulthood (Lerner et al. 1947; Jackson et al. 1961; Leers and Royce 1966). However, a role of reovirus in the pathogenesis of symptomatic infection has not been substantiated in humans. Although reoviruses have not been conclusively implicated in any human disease, this viral system has served as a model to study the manner by which other more pathogenic viruses in humans may infect the gut and gain entry into a mammalian host. The ability to manipulate the viral genetic elements has enhanced our ability to define viral proteins associated with virus delivery, entry, and infection at the primary site of entry and has been an additional rationale to study reovirus infection.

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Author information

Authors and Affiliations

  1. Research Medicine, Veterans Affairs Medical Center, Nashville, TN, 37212, USA

    E. L. Organ & D. H. Rubin

  2. Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, 37240, USA

    E. L. Organ

  3. Department of Medicine, Division of Infectious Diseases, and Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, 37240, USA

    D. H. Rubin

Authors
  1. E. L. Organ
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  2. D. H. Rubin
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Editors and Affiliations

  1. Health Sciences Center, Department of Neurology, University of Colorado, 4200 East 9th Avenue, Campus Box B-182, Denver, CO, 80262, USA

    Kenneth L. Tyler M.D.

  2. Department of Neuropharmacology, Division of Virology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA, 92037, USA

    Michael B. A. Oldstone M.D.

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© 1998 Springer-Verlag Berlin Heidelberg

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Organ, E.L., Rubin, D.H. (1998). Pathogenesis of Reovirus Gastrointestinal and Hepatobiliary Disease. In: Tyler, K.L., Oldstone, M.B.A. (eds) Reoviruses II. Current Topics in Microbiology and Immunology, vol 233/2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72095-6_4

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  • DOI: https://doi.org/10.1007/978-3-642-72095-6_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-72097-0

  • Online ISBN: 978-3-642-72095-6

  • eBook Packages: Springer Book Archive

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