Apoptosis and the Cytopathic Effects of Reovirus
Reoviruses are cytolytic viruses which cause the death of infected cells in vitro and in vivo. The relationship between events involved in the production of virus and death of the infected cell is not clearly understood. Studies of virus-induced biochemical and morphological changes in cells, i.e., cytopathic effects, have begun to define both viral and cellular factors involved in virus-induced cell death. The description and definition of apoptosis as a mechanism of cell death distinct from necrosis has provided a framework for elucidating the roles of these viral and cellular factors in the cell death process. The demonstration that reovirus induces apoptosis in vitro and in vivo identifies apoptosis as an important component of reovirus-induced cytopathic effects and tissue injury. In this chapter we review the current data describing reovirus-induced apoptosis and propose that many of the previously described cytopathic effects of reovirus infection represent events which initiate or comprise steps in the apoptotic process.
KeywordsPermeability Shrinkage Oligomer Polypeptide Compaction
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