Abstract
Many cytolytic animal viruses are capable of establishing persistent infections of cultured cells. For such persistent infections to be maintained interactions between virus and cell must be modulated such that a less cytopathic virus-host relationship is established (reviewed in Ahmed et al. 1996). Variant viruses may be selected that are attenuated in cytolytic potential, or variant cells may be selected that are less permissive for viral replication. In some cases, however, viruses and cells coevolve during persistent infection, such that selection of virus-resistant cells leads to counterselection of highly infective mutant viruses that can grow in resistant cells.
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Dermody, T.S. (1998). Molecular Mechanisms of Persistent Infection by Reovirus. In: Tyler, K.L., Oldstone, M.B.A. (eds) Reoviruses II. Current Topics in Microbiology and Immunology, vol 233/2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72095-6_1
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DOI: https://doi.org/10.1007/978-3-642-72095-6_1
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