Reovirus Capsid Proteins σ3 and µ1: Interactions That Influence Viral Entry, Assembly, and Translational Control
Mammalian reoviruses are prototypical members of the Reoviridae family. Characteristics shared by members of this family include a segmented dsRNA genome and a nonenveloped particle consisting of two or three concentric proteinaceous capsids. The ten genome segments of mammalian reoviruses together encode only 11 unique proteins. These proteins execute the reovirus replication program in a variety of cell types within diverse animal hosts.
KeywordsZinc Chromium Cysteine Carboxyl Serine
Unable to display preview. Download preview PDF.
- Dermody TS, Nibert ML, Wetzel JD, Tong X, Fields BN (1993) Cells and viruses with mutations affecting viral entry are selected during persistent infections of L cells with mammalian reoviruses. J Virol 76: 2055–2063Google Scholar
- Dryden KA, Wang G, Yeager M, Nibert ML, Coombs KM, Furlong DB, Fields BN, Baker TS (1993) Early steps in reovirus infection are associated with dramatic changes in supramolecular structure and protein conformation: analysis of virions and subviral particles by cryoelectron microscopy and image reconstruction. J Cell Biol 122 (5): 1023–1041PubMedCrossRefGoogle Scholar
- Henry GL, McConnack SJ, Thomis DC, Samuel CE (1994) Mechanism of interferon action. Translational control and the RNA-dependent protein kinase (PKR): antagonists of PKR enhance the translational activity of mRNAs that include a 161 nucleotide region from reovirus SI mRNA. J Biol Regul Homeost Agents 8 (1): 15–24PubMedGoogle Scholar
- Hooper JW, Fields BN (I 996a) Monoclonal antibodies to reovirus sigma 1 and mu 1 proteins inhibit chromium release from mouse L cells. J Virol 70(1):672–677Google Scholar
- Jayasuriya AKU (1991) Molecular characterization of the reovirus M2 gene. Microbiology and molecular genetics. Thesis, Harvard UniversityGoogle Scholar
- Morgan EM, Zweerink HJ (1974) Reovirus morphogenesis: core-like particles in cells infected at 39 with wild-type reovirus and temperature-sensitive mutants of groups B and G. Virology 59:556–565 Morgan EM, Zweerink HJ (1975) Characterization of transcriptase and replicase particles isolated fromreovirus-infected cells. Virology 68 (2): 455–466CrossRefGoogle Scholar
- Nibert ML, Schiff L, Fields BN (1996) Reoviruses and their replication. In: Fields BN, Knipe DM, Howley Fields PM (eds) Virology. Lippincott-Raven, PhiladelphiaGoogle Scholar
- Sabin AB (1959) Reoviruses. Science 130: 1387–1389Google Scholar
- Schmechel S, Chute M, Skinner P, Anderson R, Schiff L (in press) Preferential translation of reovirus mRNA by a sigma3-dependent mechanism. Virology 232:62–73Google Scholar