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Enzymatic and Control Functions of Reovirus Structural Proteins

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Book cover Reoviruses I

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 233/1))

Abstract

Viruses have evolved in many diverse ways in order to utilize efficiently their limited genetic information and successfully overcome the various defense mechanisms of different hosts. For the multisegmented dsRNA-containing reoviruses, this has apparently been accomplished at the level of the structural proteins rather than the mRNA. In reovirus infections, only full-length, unspliced viral mRNA are produced and, with one exception, each contains a single translational open reading frame. However, most, if not all, of the virion structural proteins also have enzymatic activities and/or other functions that are essential in the reovirus life cycle (Table 1). This structural protein pleiotropy is summarized in this chapter, which is based on the many studies that have correlated virion proteins with functional activities and assigned them to specific reovirus genome segments.

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  1. Center for Advanced Biotechnology and Medicine, 679 Hoes Lane, Piscataway, NJ, 08854-5638, USA

    Z. Yue & A. J. Shatkin

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  1. Z. Yue
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  2. A. J. Shatkin
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Editors and Affiliations

  1. Department of Neurology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Campus Box B-182, 80262, Denver, CO, USA

    Kenneth L. Tyler M.D.

  2. Department of Neuropharmacology Division of Virology, The Scripps Research Institute, 10550 N. Torrey Pines Road, 92037, La Jolla, CA, USA

    Michael B. A. Oldstone M.D.

Additional information

The early demonstration of reovirus gene reassortment by Bernie Fields provided fundamental insights into how reoviruses evolve, and this chapter is dedicated to his memory.

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Yue, Z., Shatkin, A.J. (1998). Enzymatic and Control Functions of Reovirus Structural Proteins. In: Tyler, K.L., Oldstone, M.B.A. (eds) Reoviruses I. Current Topics in Microbiology and Immunology, vol 233/1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72092-5_2

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